Job DescriptionCo-op Research Associate - BiologyLocation: Boston, MA
Monte Rosa Therapeutics is seeking a passionate Co-op Research Associate to assist in a variety of different technical disciplines. Monte Rosa seeks to eliminate disease causing proteins through targeted protein degradationa novel and exciting way of drugging proteins that until recently were considered un-druggable. The candidate will help on a variety of programs and technical projects from developing and characterize cellular models, or that will be used for target-identification and -validation as well as Assist in execution of a variety of assays to mechanistically understand the target of interest and to screen and characterize small molecule compounds and determine the mode of compound action, or for high-throughput compound screens to identify novel degraders. The ideal candidate is someone looking to learn a variety of cellular, biochemical or molecular techniques, is capable of multi-tasking and working in a team environment, and is curious and enjoys doing science.Principal Duties and Responsibilities:
Assist in the establishment and characterization of cell lines with specific genetic alterations (gene mutation, gene deletion, gene modifications) using CRISPR/Cas9
Simultaneously and aseptically maintain multiple unique cell lines in culture
Confirm the introduction of the genetic alternations using molecular biology assays (Western Blot, PCR).
Evaluate the effect of the genetic alternation on the cells using Next Generation Sequencing
Help to develop and run a variety of assays to screen and characterize target proteins and small molecule compounds.
Perform a variety of high-throughput Cellular Biology and Biochemical experiments and analytical assays such as ELISA, HTRF, high content, flow cytometry, and reporter assays (fluorescent and enzymatic).Requirements
- Currently in a Master degree or equivalent program in Biochemistry, Cell Biology or a life science.
Strong desire to learn the most advanced approaches to drug discovery
Experience with mammalian cell culture
Understanding of molecular biology, biochemistry techniques (e.g. Western Blot, PCR, ELISA).
Enjoys working in a team-based environment
Excellent oral and written communication skills
Interested Candidates may forward CV and Cover Letter to Careers-US@MonterosaTx.com
Monte Rosa Therapeutics rational approach in targeting disease-causing proteins for degradation will deliver pioneering therapies for cancer and other diseases. Delivering this new generation of treatments to the patients requires a conceptual change. Monte Rosa recognizes this urgent need and is missioned to develop innovative protein degraders as a solution. Combining deep knowledge, insight and leading-edge science, our integrated engine is built for that purpose.