Computational Biologist

We are actively partnered with a pioneering startup who are focused on making untreatable diseases, treatable. With an incredibly passionate team, they are looking to ensure that the patients with the worst outcomes are getting the best solutions possible.

What You'll Do:

• Partner with wet-lab groups in Analytical Genomics, Cell Engineering & Genome Modification, and Technical Operations to design studies, answer biological questions, analyze, and interpret gene editing data. This includes providing computational support for target identification, guide RNA design, and primer design for targeted genome sequencing.
• Work with cross functional teams focused on cell engineering and genome editing while designing studies and analyzing data from single-cell and bulk RNA sequencing, genome sequencing particularly targeted sequencing, flow cytometry and, ideally, multi-omics technologies.
• Proper documentation of code, workflows, and analyses including study reports for nonclinical and clinical studies and regulatory filings.
• Work with other computational biologists and computational engineers to prototype internal workflows to transition to production pipelines.
• Communicate to a broad audience with a range of technical, analytical, and biological expertise and present results on a regular basis at various group meetings.
• Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
• Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
• Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment
• Innate ability to assess talent that will help grow the organization and add the Client's culture

What You'll Bring:

• Strong publication record and / or strongly relevant work experience
• Experience with development and application of tools for analysis of guide RNAs and CRISPR-Cas / TALENs/ zinc finger nucleases including all steps for the analysis of gene editing data (on-target, off-target, translocation)
• Demonstrated proficiency in git, Python and / or R
• Strong scientific background including an understanding of molecular biology and genomics
• Demonstrated strong analytical, problem-solving abilities and decision-making skills
• Must be detail oriented, self-motivated, flexible, and able to prioritize and manage several fast-paced projects concurrently
• Outstanding verbal and written communication skills for technical and non-technical audiences
• You should be collaborative, a team player and demonstrate curiosity
• Ability to engage in crucial conversations - providing and receiving feedback
• Demonstrated record of authoring research and regulatory reports to support IND and BLA filings is preferred.
• Familiarity with multiple NGS applications in gene editing and genome modification such as TIDE, ICE, CITE-Seq, GUIDE-Seq
• Experience with AWS or similar cloud computing platforms
• Experience with workflow languages such as Nextflow

This role starts as a contract but has the potential to turn into a permanent position for the right person.