Scientist in vivo Cell Biology

Scientist, in vivo Cell Biologist

Location: South San Francisco

Position type: Regular Full Time

Walking Fish Therapeutics, Inc. is a privately-held, biotechnology company discovering and developing innovative cell-based therapeutics. Using its novel, cell-based discovery platform, Walking Fish is building a strong pipeline of oncology and regenerative medicine drug products. Walking Fish is using cell-based therapy to modulate the immune system and deliver therapeutic payloads into diseased tissue thereby minimizing systemic toxicity and allowing delivery of locally acting factors. Walking Fish has multiple patents for cell-based engineering and delivery technologies. For more information about Walking Fish, please visit Walking Fish's web site at www.walkingfishtx.com.

The Position

We are currently seeking an enthusiastic, highly motivated Scientist. As part of the In Vivo cell therapy team, the successful candidate will be responsible for developing, planning, and performing animal studies using humanized models and mouse models of human disease and supporting ex vivo analyses to support discovery and development of new therapeutics in oncology, inflammatory and other diseases.

Major Responsibilities and Duties:

• Design in vivo studies to support the goals of oncology and inflammatory disease models.
• Perform xenograft and syngeneic tumor studies to test efficacy, cell distribution kinetics, and mechanism of action of cell therapies. Hands-on work will include developing and optimizing xenograft and syngeneic tumor models, intravenous dosing of mice, and isolation and processing of mouse blood and tissue.
• Support the development of new in vivo models. May include, but is not limited to, humanized mouse models, the use of bioluminescent imaging, and in vivo models of target discovery
• Ability to perform in vitro and ex vivo work to examine drug pharmacodynamics and mechanisms of action, including: Multi-color flow cytometry to examine tumor infiltrating immune cells; Cell-based assays, including viability, cytotoxicity, and proliferation of cancer cells and activation and cytotoxicity of immune cells
• Analyze and present data as a key member of project teams representing the In Vivo cell therapy department.
• Work collaboratively with other departments on multiple projects concurrently and coordinate activities across functions.

The successful candidate will possess the following qualifications:

• PhD with at least 1-2 years of post-doctorate experience or bachelors with 6 years of experience.
• At least 2-3 years of hands-on in vivo experience designing and running in vivo models of human diseases.
• Expertise in handling and dosing mice, including intravenous, intraperitoneal, and SQ and mouse tissue and blood collection is essential.
• Experience with animal models of auto-immunity and/or inflammation is a plus.
• Hands-on experience with various in vitro laboratory techniques, including multi-color flow cytometry, qRT-PCR, ELISA, and immunohistochemistry is strongly preferred.
• Capable of working independently in a fast-paced, team-oriented environment, demonstrating multitasking capabilities.
• Excellent experimental design, troubleshooting, and data analysis skills are required.
• Great communication skills and team spirit is a must; ability to communicate results within Pharmacology and Biology teams and at project team meetings required.
• Previous industry experience is preferred.