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Senior Scientist, Cancer Biology

Employer
Plexium, Inc.
Location
San Diego County, California, US
Salary
Competitive
Closing date
Dec 8, 2021

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Sector
Consultancy/Private Sector
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
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Job Description
Company Overview

Plexium is a pharmaceutical company focused on developing first-in-class therapeutics by targeting and modulating E3 ligases. Our propriety DELPhe platform enables us to disrupt and redefine high-throughput screening through the use of miniaturization. We are leveraging our DELPhe platform to develop novel small molecule modulators of E3 ligases to uncover new therapeutic biology.

Position Summary

Plexium's biology group is seeking a highly motivated scientist to join a multidisciplinary team dedicated to the discovery of novel targeted protein degradation therapeutics. The candidate must have in-depth knowledge of cancer biology and experience with the characterization of small molecule inhibitors in various cell-based assays. This is a hands-on position that requires an ability to be productive in a rapidly evolving environment. Responsibilities include target validation and mechanism of action studies, development of disease hypotheses, and supporting lead optimization. The successful candidate will be a team player who enjoys working closely with others to solve complex problems.

Requirements

Education and Experience
  • PhD in cellular, molecular or cancer biology or related field, with relevant scientific experience in cancer biology
  • 0 - 3 years of industry experience (small molecule drug discovery preferred)


Skills and Knowledge
  • Ability to independently design, plan, execute and interpret experiments
  • Expertise in tissue culture techniques, western blot analysis, stable cell line generation, proliferation/signaling assays and multi-color flow cytometry
  • Experience with cellular mechanisms and signaling pathways regulating cancer cell growth
  • Experience with protein degradation by the ubiquitin-proteasome system (UPS) preferred
  • Expertise in target identification/validation using small-molecule inhibitors and/or genetic manipulation (si/shRNA, CRISPR)
  • Proven track record of successful scientific accomplishments, presentations and/or peer reviewed publications
  • Outstanding problem solving, troubleshooting and organizational skills
  • Excellent communication and presentation skills
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