Principal Scientist/Associate Director, Cancer Biology

Job Description
Scismic is supporting the growth of a biotech startup in San Francisco!

We are seeking an exceptional cancer biologist to join our Biology Team. In this position you will work in close conjunction with our Platform Team in the development of our core drug discovery technology. Your responsibilities will include phenotypic assay development, establishing pre-clinical in vitro / in vivo studies, performing mechanistic studies on lead drug molecules, and spearheading forays into new oncology indications.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing, and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery doubly so. We are looking for candidates who have a demonstrated ability to stick with hard problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be too.

Qualifications & Nice-To-Haves:

PhD in Cancer Biology, Cell Biology or related field

5-7+ years of industry experience

• Proficiency in:
  • Mechanistic studies of cancer cell signaling and PTM status analysis
  • Phenotypic assay development for cancer drug discovery (assay development and low/med throughput screening experience)
  • Small molecule drug development campaigns (hit finding, hit validation, dose/response studies, MOA studies)
  • Excellent cellular and molecular biology knowledge/experience (cancer cell lines, generation of stable cell lines using lenti/CRISPR systems, IP/pull down assays, flow cytometry, plasmid design)

• Experience with:
  • Target/indication selection
  • Pre-clinical and IND-enabling studies
  • Animal models of cancer (GEMM, orthotopic, xenograft models)
  • Managing CROs for in vivo studies
  • Managing a team of exceptional scientists and research associates

• Nice-To-Haves:
  • Prior experience on teams that have successfully advanced research to the clinic
  • Strong written and oral communication skills.

Benefits:

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• Reading budget! We will buy you books