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Associate Scientist (Molecular Biology) yl

Adverum Biotechnologies, Inc.
Redwood City, California, US
Closing date
Dec 8, 2021

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Academic / Research, Consultancy/Private Sector
Informatics / GIS
Salary Type
Employment Type
Full time
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Adverum is looking for an Associate Scientist with knowledge of molecular biology to join our team in our Redwood City office. This position reports to a Scientist/Team Leader. This person will be working with Assay Development, QC, and Process Development. This role is responsible for developing, qualifying, transferring, and troubleshooting molecular biology assays in support of product characterization/release and bioanalysis.

What you'll do:Work with senior scientific personnel to design, develop, qualify, troubleshoot, and transfer molecular biology assays to internal and external scientists in some subset of the following categories: AAV titer assay by qPCR/ddPCR in different stages of vector processingHost cell residual DNA assay Viral/plasmid residual DNA assayNucleic acid extractionPK/biodistribution assay to measure DNA/RNA in biological samplesCapillary Electrophoresis assaysProduct characterization assays Participate in decisions on experimental approaches and interpretation of data.Work collaboratively with different research and development departments to evaluate, develop, and implement new assay formats and/or technologies.Perform internal sample analysis as needed in support of product characterization and preclinical studies.Transfer assays and oversee work at Contract Research Organizations and in the QC group.Maintain current knowledge of regulatory requirements for bioanalytical and product characterization assays.Write test procedures, documented standard test methods, SOPs, protocols, and technical reports.Present project status updates in internal and external forums.Maintain excellent documentation of laboratory activities.Perform routine lab maintenance.Other responsibilities may be assigned as needed.

About you:Minimum of a biological science or similar Bachelor's degree with 6-8 years' of relevant experience in a biotech company, or a Master's degree with 4-5 years' of relevant experience, or an equivalent combination of education and experience.Experience in assay development is required.Ability to read and extract information from published literature and internal reports is required.Experience in the qualification/validation of quantitative assays and knowledge of FDA requirements is desired.Experience in primer/probe design for qPCR and qPCR optimizationddPCR instrument and understanding of AAV biology is strongly desired.Broad knowledge of molecular biology methods with application to gene therapy (for example, AAV titer and host cell residual DNA assays) is desired. Must be a self-starter, proactive, co-operative, and proficient at working both independently and in a small team environment.Proven initiative and demonstrated accountability in a fast-paced environment with high degree of flexibility.Detail oriented with time management skills.Excellent verbal and written communication skills.Experience in presenting data through written reports and oral presentation.Publication in a peer-reviewed journal or presentation at a conference is desired.Proficiency with GraphPad Prism, JMP, SoftMaxPro and other common analytical software desired.Experience of bioinformatics with Genbank and application to qPCR assay design is a plusProficient with MS Office and other common office software.
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