Summary The Chen Lab studies the transcriptional regulation of nuclear receptors and fusion oncoproteins by using multidisciplinary approaches, while members of the High Throughput Bioscience (HTB) Center (directed by Dr. Chen) work together on target validation, assay development, and compound screening. We investigate signaling pathways and develop chemical probes to modulate transcription, with a goal to understand transcriptional regulation and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The Chen Lab provides a unique training environment: in addition to basic research, the postdoctoral fellow will learn and gain experience in small molecule drug discovery from target validation, compound screening to preclinical mechanistic studies. Former Chen Lab postdocs have landed jobs as Assistant Professors in Universities, Senior Scientists in Pharmaceutical Companies, or Staff Scientists at St. Jude. The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, structural biologists, and technologists. (https://www.stjude.org/chen). Taosheng Chen, PhDMember (Professor), Department of Chemical Biology and Therapeutics St. Jude Graduate School of Biomedical Sciences Director, High Throughput Bioscience CenterSt. Jude Children's Research Hospital262 Danny Thomas PlaceMemphis, TN 38105-2794 USAPhone: 1-901-595-5937 Fax: 1-901-595-5715Email: email@example.comWebsite: http://www.stjuderesearch.org/chen/ Responsibilities The postdoctoral fellow will work on one or more of the following projects related to either nuclear receptors or fusion oncoproteins: * Investigate the mechanism of action of chemical probes (including bi-functional compounds such as protein degraders) * Perform structural studies and modeling of compound-protein interactions * Discover therapeutic targets by data mining followed by experimental validation * Design assays to discover small molecule modulators of transcription Minimum Education Highly motivated individuals with a strong publication record are encouraged to apply. The successful candidate will have a strong background in either cell/molecular biology or biochemistry/structural biology, experience in studying transcriptional regulation, and interest in investigating compound mechanism-of-action. Candidates must have (or soon receive) a PhD degree. Other Information COVID-19 vaccine: As of September 10, 2021, St. Jude Children's Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment. EEO Statement: St. Jude is an Equal Opportunity Employer No Search Firms: St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.