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Sr. Associate Scientist - Protein Expression and Cell Biology

Amgen Inc.
South San Francisco, California, US
Closing date
Dec 12, 2021

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Consultancy/Private Sector
Conservation science
Finance, Biology
Salary Type
Employment Type
Full time
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HOW MIGHT YOU DEFY IMAGINATION? You've earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you've worked hard to acquire and the passion you already have. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role. Sr. Associate Scientist - Protein Expression and Cell Biology Live What you will do Let's do this. Let's change the world. In this vital role you will be responsible for hands-on cell line generation, expression optimization and protein production work using various mammalian expression systems. Amgen's Therapeutic Discovery organization is seeking a motivated and collaborative protein expression and cell culture expert to join the Protein Technologies group at our Amgen South San Francisco site. Protein Technologies group is responsible for designing and producing key enabling recombinant proteins to support early discovery programs and exploring cutting-edge novel protein modalities. Scientific and technical expertise in transient and stable protein expression platforms is required for this laboratory position. Responsibilities include: understanding individual project details by literature reading and by closely working with protein design, molecular cloning, and protein purification groups, expressing recombinant constructs using mammalian cell hosts, carrying out cell biological characterization of transfected cells using IF microscopy or flow cytometry, performing small (~1-L) to mid-scale (~30-L) protein production runs using various platforms, analyzing harvested culture media by SDS-PAGE, Western blotting, Octet, etc. to determine secretory titer and protein product quality, summarizing and reporting experimental results, resolving protein expression challenges by cross-functional collaboration, following data entry and record keeping requirements, contributing to technology development initiatives through hands-on technical expertise. Win What we expect of you We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is a great teammate with these qualifications. Basic Qualifications Bachelor's Degree in Biochemistry, Bioengineering, Cell Biology, Molecular Biology or a related subject area and 5 years of scientific laboratory experience. Or Master's Degree in a related subject area and 3 years of laboratory experience. Preferred Qualifications Doctoral degree and a prior experience in recombinant protein production using mammalian expression systems in biotech/pharma industry. A demonstrated ability to solve complex technical problems and to work both independently and in cross-functional teams. Solid hands-on experience in one or more of the following areas: * Cell line and cell phenotype engineering using 293 and CHO cells. * Producing complex secretory molecules such as bi-specific and multi-specific antibodies. * Robotic liquid handling (e.g. TECAN) and high-throughput protein expression platform. * Operating and maintaining bioreactors at 5-10L scale with disposable vessels. Familiarity in the process of intracellular protein folding, assembly, trafficking, and protein secretion. Effective verbal and written communication and interpersonal skills, as well as the ability to work in a fast-paced team environment. Thrive Some of the vast rewards of working here As we work to develop treatments that take care of others, so we work to care for our teammates' professional and personal growth and well-being. * Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey * A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act * Generous Total Rewards Plan-comprising health, finance and wealth, work/life balance, and career benefits-with compensation and benefits rated above 4 stars (out of 5) on Glassdoor Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.

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