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AAV Vector Biology and Engineering Lead

Integrated Resources, Inc
Cambridge, Massachusetts, US
Closing date
Dec 2, 2021

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Academic / Research, Consultancy/Private Sector
Informatics / GIS
Genetics, Biology
Salary Type
Employment Type
Full time
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As the AAV Vector Biology and Engineering Lead you will oversee a small team to advance gene editing platform and pipeline. This role will apply new approaches to engineer and optimize AAV payloads for gene editing. This role is cross-functional and will work closely with team members in groups across the organization including disease biology, pre-clinical, manufacturing, and bioinformatics.

Key responsibilities include:
  • Manage and mentor a team working on AAV construct optimization and design
  • Develop assays for validating and optimizing Client vectors in vitro and in vivo
  • Collaborate with cross-functional teams to meet project goals and advance Client vectors into clinical pipeline
  • Work closely with key industry and academic partners
  • Present scientific plans and data to project teams and senior leadership
  • Manage collaborations with CROs and academic/industry partnerships, and facilitate technology/method transfer

About You:

We are seeking an innovative scientist with AAV payload design and optimization experience. The ideal candidate thrives on working collaboratively with multidisciplinary teams, displays outstanding communication skills, and is passionate about pioneering new gene-editing technologies to treat human disease. Other important qualities include:
  • Ph.D. in Molecular/Cell Biology, Genetics, Virology, Synthetic Biology, Bioengineering, or a closely related field
  • Experience with one or more of the following:
    • Design and delivery of viral or non-viral vectors
    • Virus/Host interactions and immunogenicity
    • Gene editing technologies such as CRISPR/Cas9
    • AAV delivery and biodistribution in pre-clinical models
  • Familiarity with state-of-the-art AAV research-grade production and analytical methods
  • Excellent bench skills with attention to detail and high standards for data integrity and quality
  • Hands-on experience with molecular biology methods with a desire to validate and implement new techniques
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