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BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. Structural biology is critical to our protein homeostasis (PH) research. High quality 3D structures of proteins and protein complexes involved in Ubiquitin/Proteasome System-mediated degradation enable our scientists to understand mechanisms of action, design ligands or drug molecules, and make predictions about new biological targets for our drug discovery efforts. A deep focus in Oncology puts our resources squarely on projects of intense biomedical interest. Job Description
The team leader will direct the research of a talented group of structural biologists who have dedicated experience and expertise in the PH field. There is opportunity to have a real-time, high value impact on the ongoing projects as well as chart the future of our research efforts by capitalizing on structural insights (i.e., uncover mechanisms of action, define binding modes, identify degrons, etc.). The leader will interface with chemistry, biology, and Computational-Aided Drug Design scientists working on our PH projects. There are additional opportunities to interact across our structural biology community of practice. The PH Structural Biology team will be part of an exciting and vibrant group that includes proteomics, biophysics, and cell biology that are dedicated to PH. We are seeking a passionate leader who wants to bring impactful structural biology insights to bear on a burgeoning portfolio of PH targets to help bring novel therapies to patients. Job Responsibilities
Responsible for building and leading an internal team of 6-8 structural biologists working in PH Lead and contribute to the structural biology strategy for CRBN-mediated degradation of neosubstrates of interest Participate in a key alliance established to identify neosubstrates across cell lines representing human tumors and other diseases Key contributor to leveraging PH-related CryoEM efforts via new collaboration with Princeton University Plan, execute, and report on studies resulting in novel structures for CRBN E3 Ligase Modulators (CELMoDs) and Ligand Directed Degraders (LDDs) Lead structural biology efforts pursuing novel ligands for E3 ligases Represent the PH Structural Biology at project level and departmental meetings Lead and participate in departmental initiatives and represent PH Structural Biology on cross-functional initiatives / work streams / taskforces Interact closely with biology and chemistry on drug discovery teams Work with Business Development teams and provide critical expertise to assess external opportunities Provide mentorship and career development guidance to staff Required Qualifications
A PhD with post-doctoral training in structural biology 8+ years of experience in an academic and/or industrial setting solving complex protein structures A minimum of 2-3 years of Cryo-EM experience and at least 4 years leading MA- and PhD-level scientists. In-depth knowledge of current practices and issues in X-Ray, Cryo-EM and other techniques Working knowledge of proteomics, protein expression, biophysics, biochemistry and bioassay development Strong written and oral communication skills necessary to deliver scientific results and presentations clearly Demonstrated ability to thrive in a multidisciplinary team and inspire mutually-beneficial collaborations to drive the development of PH therapeutics Keen desire to grow and develop the careers of team members Preferred Qualifications
- Deep experience in the structural aspects of protein degradation pathways is strongly preferred
- Local and international travel for conferences may be required depending on project needs up to 5% of the time
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