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Director, Protein Homeostasis Structural Biology

Bristol Myers Squibb
San Diego County, California, US
Closing date
Dec 4, 2021

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. Structural biology is critical to our protein homeostasis (PH) research. High quality 3D structures of proteins and protein complexes involved in Ubiquitin/Proteasome System-mediated degradation enable our scientists to understand mechanisms of action, design ligands or drug molecules, and make predictions about new biological targets for our drug discovery efforts. A deep focus in Oncology puts our resources squarely on projects of intense biomedical interest. Job Description The team leader will direct the research of a talented group of structural biologists who have dedicated experience and expertise in the PH field. There is opportunity to have a real-time, high value impact on the ongoing projects as well as chart the future of our research efforts by capitalizing on structural insights (i.e., uncover mechanisms of action, define binding modes, identify degrons, etc.). The leader will interface with chemistry, biology, and Computational-Aided Drug Design scientists working on our PH projects. There are additional opportunities to interact across our structural biology community of practice. The PH Structural Biology team will be part of an exciting and vibrant group that includes proteomics, biophysics, and cell biology that are dedicated to PH. We are seeking a passionate leader who wants to bring impactful structural biology insights to bear on a burgeoning portfolio of PH targets to help bring novel therapies to patients. Job Responsibilities Responsible for building and leading an internal team of 6-8 structural biologists working in PH Lead and contribute to the structural biology strategy for CRBN-mediated degradation of neosubstrates of interest Participate in a key alliance established to identify neosubstrates across cell lines representing human tumors and other diseases Key contributor to leveraging PH-related CryoEM efforts via new collaboration with Princeton University Plan, execute, and report on studies resulting in novel structures for CRBN E3 Ligase Modulators (CELMoDs) and Ligand Directed Degraders (LDDs) Lead structural biology efforts pursuing novel ligands for E3 ligases Represent the PH Structural Biology at project level and departmental meetings Lead and participate in departmental initiatives and represent PH Structural Biology on cross-functional initiatives / work streams / taskforces Interact closely with biology and chemistry on drug discovery teams Work with Business Development teams and provide critical expertise to assess external opportunities Provide mentorship and career development guidance to staff Required Qualifications A PhD with post-doctoral training in structural biology 8+ years of experience in an academic and/or industrial setting solving complex protein structures A minimum of 2-3 years of Cryo-EM experience and at least 4 years leading MA- and PhD-level scientists. In-depth knowledge of current practices and issues in X-Ray, Cryo-EM and other techniques Working knowledge of proteomics, protein expression, biophysics, biochemistry and bioassay development Strong written and oral communication skills necessary to deliver scientific results and presentations clearly Demonstrated ability to thrive in a multidisciplinary team and inspire mutually-beneficial collaborations to drive the development of PH therapeutics Keen desire to grow and develop the careers of team members
Preferred Qualifications
  • Deep experience in the structural aspects of protein degradation pathways is strongly preferred

Travel Required
  • Local and international travel for conferences may be required depending on project needs up to 5% of the time

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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