Senior Research Associate/Scientist I, Biology
Monte Rosas rational approach to targeting disease-causing proteins for degradation will deliver pioneering therapies for cancer and other diseases. Delivering this new generation of treatments to patients requires a conceptual change. Monte Rosa recognizes this urgent need and is missioned to develop innovative protein degraders as a solution. Combining deep knowledge, insight and leading-edge science, our integrated engine is built for that purpose.
Monte Rosa Therapeutics is seeking an energetic and self-motivated scientist to join our innovative team working towards discovery of unique molecular glue degraders for the treatment of targeted patient populations in indications including auto-inflammatory disease, hematology and oncology. This is a lab-based position that offers the opportunity to impact projects as they progress from target validation and hit-finding, through to lead optimization and pre-IND studies.
The candidate will be a highly motivated experimentalist with demonstrated collaborative skills and a strong desire to contribute to project success.
Principal Duties and Responsibilities
* Validate molecular glue degrader hits by employing techniques such as Western blot, flow cytometry, ELISA, qPCR to assess viability, target and biomarker expression, proliferation.
* Develop, validate and independently execute cell-based assays using cell lines and primary human hematopoietic cells.
* Participate in team drug discovery biology efforts to perform target validation, discovery toolkit development and hit-to-lead selection and progression. Opportunity to champion projects as they progress to hit-to-lead and beyond.
* In collaboration with the team:
* utilize literature and internal bioinformatics data to design and test hypotheses for drug targets
* identify pharmacodynamic assays for utility in pre-clinical and clinical setting; define PK/PD/efficacy relationships and test patient selection strategies.
* Interpret, present and report research findings at internal meetings.
MS or PhD equivalent in Immunology, Cell Biology or Cancer Biology with 3+ years hands-on experience in drug discovery research in a pharmaceutical setting
Extensive experience with protein detection/quantitation methodology (e.g., Western blotting, JES) and antibody reagent validation required
Multiparameter flow cytometry and immune cell assay experience required (e.g. T cell proliferation assays); ex vivo cell isolation and analysis experience preferred
Prior experience preparing drug dilutions and performing drug sensitivity experiments required
Previous work with culture and maintenance of mammalian cell lines, including transfection and transduction techniques, as well as stable cell line generation; prior experience culturing/manipulating primary immune cells preferred
Ability to maintain timely and detailed notes using electronic lab notebook as well as demonstrated experience using Microsoft Excel and GraphPad Prism
Excellent interpersonal skills and willingness to learn a variety of new techniques and biological approaches; ability to work in a matrixed team and adapt to rapidly changing priorities and deadlines