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Scientist, Ocular Biology

Alloy Therapeutics, Inc.
Menlo Park, California, US
Closing date
Dec 3, 2021

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Scientist / Senior Scientist, Ocular Biology - Menlo Park, CA


The Opportunity

Alloy Therapeutics' affiliated venture studio is building a first-in-class ocular company in the San Francisco Bay Area, focused on early treatment for the prevention of blindness. This is an opportunity to be an early member of a growing team. We utilize the latest technology, focusing on nucleic acid modalities while building a best-in-class iPSC platform. Alloy Therapeutics' venture studio partners closely with a tight-knit group of serial entrepreneurs and seasoned drug hunters to efficiently launch new asset-centric biotech companies. Team members of these emerging companies get hands-on exposure to cutting-edge science and contribute to the earliest stages of drug discovery and company building, turning ideas into meaningful therapies for patients.

As part of the broader Alloy Therapeutics ecosystem, our team enjoys access to a global scientific community committed to making better medicines together. Alloy works across multiple disease indications and drug modalities, democratizing access to tools, technologies and services that are foundational for discovering and developing therapeutic biologics. Members of our team have the unique opportunity to be part of a small, highly-focused team, while gaining access to an extensive network and career opportunities across Alloy. We care deeply about mentorship and invest heavily in enabling the long-term career interests of our team.

Who You Are

We are seeking exceptional, hands-on, entrepreneurial scientists to lead and contribute to challenging projects in drug discovery for ocular disease. We work across boundaries to tackle whatever experiment, assay, or screen is necessary to develop high-impact medicines. The projects within this team require deep knowledge in genetics, biochemistry, and molecular biology, as well as expertise and interest in applying pioneering techniques. You have technical strengths in the use of IPSC and other cell-based models of ocular biology and a keen understanding of ocular biology in vivo . Your knowledge of tissue markers in disease is an important contributor to your success. Working from this foundation, you will be a key contributor in a small and tightly focused team rapidly and efficiently designing molecules that prevent blindness. We hope to hear from you!

Your Role In Leading Programs
  • You will work in a team to drive towards milestone completion at hyperspeed
  • You will be involved in all biology aspects of programs, including independent design, execute and analyze experiments in support of target validations, therapeutic lead identification, and optimization towards IND
  • You will be a vigorous contributor to a scientific culture that is curious, rigorous, and directed at solving important problems
  • Communicate findings and implications to senior leadership
  • Help drive overall preclinical strategy
  • Collaborate with the business development team to assess and understand a variety of neurological diseases
  • Use a variety of biochemical, cellular, genetic, and pharmacological techniques to advance multiple candidates from discovery research to clinical development

The Skills And Expertise You Bring
  • Ph.D. with 2+ years of postdoctoral experience, or equivalent expertise in a relevant scientific field (e.g., neuroscience, cell biology, etc.)
  • Demonstrated record of achievement as evidenced by publications
  • Solid understanding of ocular diseases (IE blindness, AMD)
  • Experience working with induced pluripotent stem cells(iPSCs) (generation and validation, maintenance, and differentiation), differentiated RPE
  • Proficiency in microscopy (confocal, high content screening, etc.)
  • Experience with a wide range of biophysical, biochemical, molecular, and cellular biology techniques, functional assay development, immunohistochemistry (IHC), ELISA, Western blot, qPCR, RT-PCR, and RNA-seq
  • Creative biology skills, the ability to utilize your expertise to understand biological mechanisms; independently conceive, develop and execute critical experiments and appropriate assays to achieve project goals
  • Strategic thinking skills, with a high degree of independence, self-motivation, and attention to detail
  • Experience in planning and supervising the execution of experiments by scientific colleagues
  • Communication and soft skills with success in a diverse scientific environment
  • Have the ability to manage multiple assignments effectively in a quickly evolving environment
  • Outstanding communication and team skills
  • Self-starter who is highly motivated to move quickly, get your hands dirty, and adapt rapidly

Preferred Qualifications And Skills
  • Industry experience is a plus
  • Exposure to nucleic acid modalities including siRNA, antisense oligonucleotide (ASO), mRNA technology
  • Direct experience in blindness disease is a plus
  • Direct experience in animal models of ocular disease, including neuropathological analyses, is a plus
  • Proficiency in fluorescence microscopy and image analysis is a plus
  • Demonstrated ability to personally contribute to IND-enabling work in close collaboration with a team
  • Thrive and energized by a fast-paced start-up environment

Benefits Include
  • Competitive base salary based on the position and your experience level
  • Significant opportunities for advancement and mentorship inside Alloy, through our venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
  • Equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental, and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through an individualized professional development plan for all employees to ensure good role and skill fit, whether here or your next biotech company
  • Additional benefits including adoption support, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development, and others

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