Principal Scientist, Computational Biology - Infectious Diseases Discovery - South San Francisco, CA

Johnson & Johnson
San Francisco, California, US
Closing date
Dec 1, 2021

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Janssen BioPharma, Inc., a division of Johnson & Johnson's Family of Companies, is recruiting for a Principal Scientist, Computational Biology - Infectious Diseases Discovery to be located in either South San Francisco, CA or Spring House, PA.

We are looking for an individual with interest and experience developing computational biology strategies, analyzing multi-omics data, and supporting research and development projects in infectious disease (ID) discovery programs.

The highly motivated Principal Scientist in Computational Biology will join us in our efforts to discover novel interventions for treating or preventing infectious diseases. The successful candidate will be able to leverage multi-omics, host/pathogen genomics, immunology, phenotypic, clinical, and biomarker using advances analytics and ML to advance our drug discovery. As a Principal Scientist you will work with limited supervision in cross functional teams of infectious disease scientists to support computational approaches in the identification and validation of novel targets, as well as discover and characterize novel interventions.

Responsibilities Include
  • Provide computational biology leadership for Janssen's ID Discovery effort with focus on chronic infections (Hepatitis B) and bacterial drug resistance.
  • Integrate with project teams to provide computational solutions for infectious disease drug discovery programs.
  • Contribute to preclinical study design in the acquisition of pathogen or host genomics, metagenomics, transcriptomics, proteomics, metabolomic or high dimensional flow cytometry data.
  • Analyze host or pathogen genomic data, efficacy biomarker data, or multi-omic data.
  • Supervise junior scientists to execute data analysis plans and present actionable results
  • Lead and initiate both internal and external collaborations to support corporate long-term goals
  • Support target or pathway identification and validation activities
  • Characterize host or pathogen resistance mechanisms
Contribute to the ID bioinformatics strategyWork with R&D IT colleagues and statistical scientists to implement best practicesCollaborate with academic and external partners aimed at gaining valuable insights from innovative data science technology and state-of-the-art analytic approaches.Communicate key results to senior leadership and write reports for publication or regulatory submission.

  • A Ph.D. degree with at least 5 years of relevant experience is required
  • Demonstrated expertise in computational biology, bioinformatics, or other relevant discipline with the use of computational approaches is required
  • Proficient in computational biology programming skills and the use of languages such as R or python in the analysis of genomic and bioinformatic data is required
  • Documented experience analyzing and integrating multi-omic datasets that may include one or more of the following: RNAseq, DNAseq, GWAS, 16S or Metagenomic data, single cell sequencing data, proteomics, metabolomics, or high dimensional flow cytometry data is required
  • Knowledge of machine learning algorithms, exploratory data analysis, pathway data analysis, statistical modeling is preferred
  • Experience working in pharmaceutical or biotech industry with understanding of drug discovery and development is required
  • Excellent communication, interpersonal, and written skills is required
  • This position may be located in either South San Francisco, CA or Spring House, PA and may require up to approximately 10% travel

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location

United States-California-South San Francisco-260 E. Grand Avenue

Other Locations

United States-Pennsylvania-Spring House


Janssen BioPharma, Inc. (6224)

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