This job has expired

Associate Director/Director, Early Target Biology

Exo Therapeutics
Watertown, Massachusetts, US
Closing date
Dec 3, 2021

View more

Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
You need to sign in or create an account to save a job.
Associate Director/Director, Early Target Biology

About the company

Exo Therapeutics ( is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company's ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company's team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.


Exo Therapeutics seeks a strong leader to oversee our Early target biology efforts and provide strategic and technical expertise for Exo's research portfolio. You will be an integral part of the biology leadership team and working cross functionally to drive target identification and validation. You will work closely with the bioinformatics, computational biology, Data sciences and the broad platform team to mine databases and identify new opportunities to drug exosites on targets of interest to inhibit disease relevant biology. You will have the opportunity to interface with all levels of our organization to deliver scientific excellence, as we expand the boundaries of research for patients.

  • Leading a group tasked with developing and implementing strategies to identify and validate targets prior to portfolio entry across Exo's Therapeutic Areas, including oncology, autoimmune diseases, and rare diseases
  • Work closely with the platform team to bring new targets to the portfolio with strategic value of targeting exosites for better therapeutic window or opportunities to drug intractable targets
  • Work with the other cross functional teams, including bioinformatics, biochemistry, chemical biology, screening, and chemistry to validate targets of interest for nomination into the portfolio
  • Actively mentor and develop outstanding scientists to fostering a culture of engagement and scientific rigor
  • Be accountable for devising and championing the development and application of state-of-the-art approaches for target identification alongside the bioinformatics and computational chemistry teams
  • Develop and implement technologies needed for target validation, including CRISPR/Cas9, RNA-seq, ATAC-seq, single cell RNA-seq and others as needed for validating targets of interest
  • Participate in the global scientific community through attendance at scientific conferences and publication of novel research findings in peer-reviewed, high-quality journals

Required Qualifications
  • Ph.D. with 10+ years of experience in biology, with 5+ years spent in identifying new targets for the portfolio
  • Deep expertise in oncology disease targets/pathways, understanding their relevance and identifying systems for their validation
  • Strong understanding of functional genomics approaches and its role in the target validation
  • Experience in working with bioinformatics group to mine genomics, gene expression, CRISPR and other databases for identification of new targets
  • Good understanding of development challenges/opportunities for other relevant therapeutic areas such as autoimmunity or rare diseases is a plus
  • Previous experience of effective team-leading is highly desirable.
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert