Scientist I/Scientist II, RNA Biology/Functional Genomics

Employer
Biogen
Location
Cambridge, Massachusetts, US
Salary
Competitive
Closing date
Dec 1, 2021
Job Description

RNA Biology/Functional Genomics- Scientist I, Genomic Targets Biology

About This Role

The Genomic Targets Biology group is seeking a highly skilled and motivated RNA Biology and Functional Genomics scientist to join a dynamic team dedicated to understanding the molecular basis of and developing novel therapeutics for neurological disorders. In this role, you will work independently and with other experimentalists, computational biologists, and statistical geneticists to exploit our understanding of how genetic variation and RNA metabolism impact disease. This is primarily a laboratory-based position for a scientist with strong molecular and cellular biology skills and deep understanding of RNA biology to study how the transcriptome and proteome is regulated and how this regulation may be leveraged for therapeutic advantage.

What You'll Do
  • Partner with scientists to identify key questions and priorities that RNA biology and functional genomics experiments can impact
  • Deliver experimental results that validate novel therapeutic targets and define therapeutic strategies to project teams
  • Develop and optimize high throughput RNA assay platforms to enhance Biogen's drug discovery pipeline
  • Work with external collaborators using cutting edge methodologies to functionalize genetic variation and their impact on RNA metabolism
Who You Are

You have deep technical expertise your field, a passion for doing science, and ability to communicate effectively with molecular and computational scientists. You have a curiosity to investigate new methods and the ability to modify and evaluate whether fit for purpose.

Why Biogen?

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We are investing in translational biology, human genomics, and advanced analytics to address scientific questions to support the discovery and development of the next generation of therapeutics. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients' lives and on changing the course of medicine.

Qualifications

Required Skills
  • Ph.D. in Molecular and Cellular Biology, Genetics, Genomics, or related field
  • Advanced experience with RNA assays (such as qRT-PCR, RT-ddPCR, RACE) and genomic/transcriptomic approaches (such as RNA-seq, CLIP-seq, Ribo-seq) to solve biological problems
  • Expertise in functional genomics assays, including antisense oligonucleotide (ASO)-mediated gene regulation, sh/siRNA treatment, CRISPR/Cas9 engineering
  • Demonstrated ability to work independently to design, execute, and troubleshoot experiments
  • Proficiency in computational approaches to next-generation sequencing data analysis
  • Excellent collaboration, organizational, and communication skills and an ability to work well in a team setting
  • Sharp ability to learn and adapt to work on new tasks and projects that are not initially familiar
Preferred Skills
  • Experience in assay development and high throughput automation
  • Prior study of noncoding RNA and regulation
Additional Information

All your information will be kept confidential according to EEO guidelines.

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