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Principal Scientist / Associate Director of Neurobiology

Employer
Stratacuity: Proven Scientific Placement
Location
Cambridge, Massachusetts, US
Salary
Competitive
Closing date
Nov 27, 2021
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Principal Scientist/Associate Director, Biochemistry (Neuroscience)
Cambridge, MA

Principal Scientist / Associate Director of Neurobiology 1150419

Job Scope & Purpose:

Our engaged client is an exciting new biopharmaceutical company dedicated to the development of novel small-molecule therapeutics for Alzheimer's disease and Parkinson's disease based on strong human genetic framework and over 20 years of basic and translational research insight from the founders' laboratories at Harvard Medical School.

Our Client is seeking an innovative, highly motivated, intellectually curious and team-oriented Principal Scientist to support their biology drug discovery efforts. You would join a dynamic, diverse and inclusive team with an opportunity to grow into a leadership role as they continue to expand their research team. As an integral part of the research team, you will help direct their small molecule drug discovery strategy on multiple CNS programs from hit-to-lead through lead optimization and to ultimately deliver drugs that will impact patients' lives.

Primary Job Responsibilities:
  • Contributes scientifically and strategically on the development of novel cellular, biochemical and enzymatic assays.
  • Establishment of "in house" biochemical and cell-based screening assays.
  • Responsible and accountable for the experimental science and project management of high-throughput screening studies performed through CRO collaborations.
  • Experience in designing molecular biology experiments including sequence analysis, qPCR, RT-PCR, restriction digest, mutagenesis, Southern blotting, northern blotting, gel electrophoresis and providing mentorship support for the biology team.
  • Experience in designing biochemical experiments including protein quantification, immunoprecipitation, immunoblotting, ELISA and providing mentorship support for the biology team.
  • Design, execution and troubleshooting of assays supporting target ID/validation in CNS disease programs.
  • Develops and optimizes internal and external compound testing workflows for IND candidate selection.
  • Frequent presentations of data to the scientific and management team.
  • Oversees, mentors and trains research associates and junior staff.
  • Maintains scientific and technical expertise through current scientific literature, attending conferences, and developing relationships with key opinion leaders.
  • Provides support for a multidisciplinary team of internal scientists and external consultants in the execution of IND applications.

Primary Job Requirements:
  • Ph.D. in Biology, Cell Biology, Molecular Biology, Biochemistry or related field and with 5+ years of relevant experience in the Pharma/Biotechnology industry is required.
  • Previous work on CNS targets and/or experience in Alzheimer's/Parkinson's drug development is preferred but not required.
  • Experience with mammalian cell culture, stable cell line generation, and transfection/transduction techniques (cDNA, CRISPR, lentivirus, AAV).
  • Expertise in Biochemistry-based assay development and compound testing.
  • Experience in molecular biology techniques such as DNA/RNA manipulation, and PCR-based assays.
  • Track record of advancing novel therapeutic agents from discovery into preclinical and ideally subsequent clinical development.
  • Prior experience working with transgenic animal models and running in vivo behavioral assays is a plus, but not required.
  • Excellent verbal and written communication and interpersonal skills to work within a project team setting, across functions, and within academic and industry collaborations.

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.

Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at employeeservices@apexsystemsinc.com or 844-463-6178.

Apex Systems dba Stratacuity, is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law.
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