Senior Research Associate, Cell Biology

Company

Therini Bio, Inc. is a biotechnology company dedicated to the research and development of novel therapeutics for the treatment of inflammatory diseases due to vascular dysfunction. The current therapeutic target is based on novel findings by the Akassoglou lab at Gladstone/UCSF that implicate fibrin as a key driver of neuroinflammation. This is an exciting chance to apply your skills as a hands-on, highly qualified and experienced biotech accounting manager to be part of a dynamic team. The successful candidate will be responsible for designing and executing cell and flow-cytometry-based assays and assist the biology team in development of pre-clinical disease models and mechanistic efficacy studies and biomarker development to support the selection, optimization, and manufacturability of candidate monoclonal antibodies. Therini is located in Lilly Gateway Labs in South San Francisco. This brand-new facility is designed specifically for early stage biotech companies and offers a dynamic work environment. This position reports to the Head of Biology.

Roles and Responsibilities

• Design and execute in vitro/ex vivo cell -based assays using flow cytometry, microscopy and plate-based ligand binding assays with primary cells from human and mouse tissues, as well as cell lines
• Support development of pre-clinical disease models for inflammation and neuroinflammatory diseases and mechanistic efficacy studies to assess activity of monoclonal antibodies
• Assist with biomarker development to identify potential clinical indications
• Generate, collect, analyze data and present scientific findings at internal research meetings
• Collaborate with internal scientists and external collaborators to design and troubleshoot experimental protocols to optimize endpoints
• Coordinate with external collaborators regarding acquiring samples from in vivo animal models and human samples for internal analysis
• Other projects, as assigned

Qualifications and Expertise

• Bachelor's or Master's degree in Biological Sciences or related discipline with at least 5 years of post-degree relevant experience in an academic or industry experience
• Pharma/biotech experience is required
• In-depth knowledge of cell biology is required
• Working knowledge of immunology, inflammation and/or neurobiology is preferred
• Hands-on expertise with mammalian cell culture, human and mouse primary cell culture is required
• Expertise in standard cellular assays and techniques, including cell isolation, cell culture, flow cytometry, and ELISA is required
• Experience with performing basic in vivo animal model techniques (animal handling and injection) and tissue collection is preferred
• Track record of staying up to date with the latest developments in the field, and a willingness to learn additional related skills as needed
• Excellent planning, organization and time management skills, including the ability to support and prioritize multiple projects
• Generate, collect, analyze and present experimental data in team meetings
• Experience working in a cross disciplinary environment is preferred
• Excellent English oral communication skills in a scientific setting are required
• Excellent technical writing skills and ability to prepare written reports are preferred
• Proficiency in Microsoft Office Programs
• The candidate must be highly motivated; able to work independently with minimal supervision; respond to changing priorities and short lead times for multiple tasks; willingness to acquire new skills; and be able to identify problems and work toward solutions

Why Work for Us?

• Join our vision to leverage Dr. Akassoglou's biological insights to novel pathways impacting brain health and to develop new molecules that reduce neuroinflammation and reduce damage to neurons
• Opportunity to translate breakthrough biological insights into innovative drugs with an innovative class of therapeutics for the treatment of numerous diseases with vascular damage including Alzheimer's Disease
• Therini's employees are passionate, engaged and extremely motivated to succeed in identifying novel treatments for patients suffering from neurodegenerative diseases
• Our environment is international, progressive and collaborative, our attitude is focused and pragmatic
• Compensation is competitive when compared to industry standards and commensurate with experience and includes benefits

If you would like to be considered for an opportunity at Therini, please submit your resume with the title of the position in the subject line to careers@therinibio.com.

Therini is an equal opportunity employer.

Note to Recruitment Agencies: Please do not forward any agency resumes. Therini is not responsible for any fees related to resumes that are unsolicited.