NIH-NINDS- Animal Biologist

Employer
Axle Informatics
Location
Rockville, Maryland, US
Salary
Competitive
Closing date
Dec 6, 2021

View more

Sector
Academic / Research
Field
Informatics / GIS
Discipline
Other
Salary Type
Salary
Employment Type
Full time
Overview:

Overview

Axle Informatics is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Overall Position Summary and Objectives Establish and maintain a record of laboratory supply usage; order, ship and receive lab supplies; document the usage of general laboratory supplies; communicate with vendors and suppliers about orders as well as be responsible for breeding and training transgenic mice. Work location Bethesda MD.

DELIVERABLES

Meet with lab members to present updates.

Work products and documents related to establishing and maintaining records of laboratory supply usage; order, ship and receive lab supplies; document the usage of general laboratory supplies; communicate with vendors and suppliers about orders

Work Products and documents related to maintaining laboratory equipment; communicate with vendors for laboratory equipment service, repair and maintenance

Work Products and documents related to ensuring lab safety by making sure that all chemicals, especially flammable chemicals, are properly stored, used and disposed

Work Products and documents related to keeping track of drug logs and making sure all drugs are properly logged and used within expiration dates; replace sharp containers when necessary

Work Products and documents related to preforming Immunohistochemistry

Statement of work

Studies the basic principles of animal life and the effects of varying environmental factors.

Conduct behavioral testing and perform surgery on small animal models

Perform behavioral assays in association with the primary research project

Coordinate husbandry, animal care and enrichment activities to maintain a clean, safe and regulatory compliant animal research program

Work with staff to manage and conduct behavioral training and testing of animals for users of the Section

Conduct animal behavioral testing, including T-maze, step down, conditioned place preference aversion, oral, inhalation and intravenous drug self-administration, forced-swim test, hot-plate, tail-flick, von Frey, locomotion, elevated plus maze, open-field, novel object recognition, ultrasonic vocalization recording and startle reflex

Conducts research and performs experiments on the selection and breeding of animals.

Develop and maintain a spreadsheet of animal breeding records; record lineage, genotype, birth, death and experimental use of each animal

Set up animals to be available in numbers and at the time required

Develop and maintain a breeding database to record all animals in the breeding colony

Anticipate animal needs for lab research and colony maintenance; adjust the number of breeding pairs accordingly

Determine best type of breeding units to set up for lab needs, including but not limited to continuous pairs, harems, and timed-pregnancies

Maintains animal colonies.

Manage and breed animal colonies; genotype animals and report genotyping results to staff

Communicate and collaborate with investigators regarding colony and support duties

Work with staff to maintain, breed, genotype and phenotype transgenic animal colony; maintain records of animal colony

Handle, dissect and euthanize animals

Maintain animal colony, including general husbandry, breeding, plug checks, weaning, tagging animals and obtaining tail or ear snips for genotyping, and euthanasia

Performs simple surgeries on animals.

Handle, dissect and euthanize animals

Perform skilled routine surgical procedures in support of on-going animal studies

Develop new surgical or animal handling techniques as needed to support projects

Perform complex surgical techniques, necropsies, blood and tissue sample collection

Prepare animals for surgery and ensure proper disposal of animal carcasses

Prepares and analyzes animal tissues.

Maintain animal lines in transgenic facilities

Harvest and collect animal embryos, tissues, and organs

Perform a variety of specialized tissue fixation, embedding, sectioning and staining techniques

Perform analysis of animal tissues; prepare frozen slices and paraffin sections, appropriately stained to demonstrate normal and abnormal structures

Performs molecular biology techniques.

Perform a variety of specialized tissue fixation, embedding, sectioning and staining techniques

Perform Immunohistochemistry and assist lab members with checking the expression of fluorescent proteins in vivo using mouse imaging method

Performs immunohistochemistry on animal tissues.

Perform light and confocal microscopy

Work with staff to process tissue for immunohistochemistry

Perform Western Blot, immunohistochemistry and immunofluorescence

Perform molecular biology and cloning techniques, tissue histochemistry and immunohistochemistry

Analyzes experimental data.

Update and maintain laboratory notebooks and databases; collect, analyze and interpret data

Perform quantitative analysis; data analysis, figure preparation, and image acquisition; maintain complete and detailed records of all experiments

Collect, organize and record experimental data for publication and future reference by others

Collate, edit and archive electronic and paper laboratory files, notebooks and databases

Perform computer analysis and use computer software to prepare images

Edits and writes research papers and protocols.

Prepare reports and manuscripts based on experimental results

Participate and collaborate in the preparation of scientific publications for peer reviewed journals based on the results

Work with staff on the preparation of data and images for use in research presentations and publications

Write and edit drafts for journal submission; read manuscript drafts of other laboratory members

Edit and write research papers and protocols

Selects, devises, plans, and executes the most appropriate experiments for analysis and interpretation of data, for developing strategies, for pursuing significant observances, and for ensuring accuracy of data.

Work with staff on the modification of laboratory protocols and experiments based on literature findings 3

Search and review literature related to project; summarize and evaluate findings 4

Document all laboratory procedures, experiments and results; maintain and update laboratory notebooks and databases 5

Develop, validate, perform and interpret a variety of complex experimental techniques and procedures; work with staff to develop procedures addressing new animal study needs, logistics, modifications to standard operating procedures, and/or existing guidelines to resolve technical problems 2

Work products and documents related to establishing and maintaining records of laboratory supply usage; order, ship and receive lab supplies; document the usage of general laboratory supplies; communicate with vendors and suppliers about orders 1

1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked

Qualifications:

Minimum Bachelor's Degree in Biology

Certifications & Licenses

Bachelor's or Master's degree in in Biological Sciences or other related discipline; three (3) years of specialized experience plus a Bachelor's degree is equivalent to a Master's degree.

Skills (Ranked By Priority)

Minimum of three (3) years of experience in maintaining mouse colonies

Minimum of three (3) years of experience in Molecular Biology, immunohistochemistry, or a related field.

Experience in performing surgical procedures with small animals

Strong communications skills, both oral and written

Excellent analytical, organizational and time management skills.

Ability to problem solve and work independently.

1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked.

Benefits

100% Medical Dental & Vision Coverage for Employees​

Educational Benefits for Career Growth​

Paid Time Off (Including Holidays) ​

Employee Referral Bonus ​

Profit Sharing

401K Matching​

Flexible Spending Accounts:

Healthcare (FSA)

Parking Reimbursement Account (PRK)

Dependent Care Assistant Program (DCAP)

Transportation Reimbursement Account (TRN)

The diversity of Axle's employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact .

Disclaimer: The above is meant to illustrate the general nature of work and level of effort being performed by individual's assigned to this position or job . This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job or responsibilities as needed.

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