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Senior Research Associate, Synthetic Biology

Employer
National Resilience
Location
La Jolla, California, US
Salary
Competitive
Closing date
Dec 1, 2021

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Sector
Academic / Research
Field
Informatics / GIS
Discipline
Genetics, Biology
Salary Type
Salary
Employment Type
Full time
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Position Summary

This role will be responsible for designing, performing, analyzing, and documenting experiments to support genome engineering research within Resilience R&D. They will work closely to assist scientists and engineers to develop and test workflows and hypotheses. The ideal candidate will have a proven track record of successfully carrying out laboratory SOPs independently. This role requires excellent verbal and written communication.

Job Responsibilities

  • Working with scientists and engineers, design knock-outs, knock-ins, and screening approaches to understand cell biology.
  • Track new techniques and technologies in the field of new nuclease designs and optimization (i.e. Base editing, Prime editing)
  • Prepare presentations and present scientific topics and experimental methods you are working on.
  • Help develop and pilot new laboratory protocols and standard operating procedures with the research team.
  • Maintain clear documentation of experimental setup, reagents used, and data generated using best practices and electronic laboratory notebooks.
  • Assist in organzing electronic laboratory notebook (ELN) contents and laboratory information management systems (LIMS)contents.
  • Perform routine laboratory operations: order and organize laboratory supplies, coordinate cell line management, dispose of dispose of biological and chemical waste; track research team laboratory trainings;
  • Participate in daily Agile stand-ups and weekly sprints with other members of the research team.


Qualifications

  • B.S or M.S. in a biology-related field (e.g. molecular biology, genetics, synthetic biology, immunology, bioengineering).
  • 0-2 years of wet lab experience including operating scientific instrumentation such as thermocyclers, fluorescent microscopes, and gel electrophoresis systems.
  • Significant experience in bacterial and mammalian cell culture systems and trained in aseptic technique.


Preferred Experience

  • Experience with CRISPR systems, experimental protocols, and genotyping analysis methods
  • Ability to use single cell phenotyping technologies (e.g. flow cytometry / FACS-based analysis)
  • Hands-on lab knowledge and experience with current and next-gen genome engineering and sequencing technologies
  • Knowledge of and experience with molecular biology and/or synthetic biology experimental approaches
  • Experience in designing DNA and RNA sequences (plasmids and maps, primers, guide RNA, siRNA).
  • Experience in interfacing with laboratory automation (e.g. automated liquid handlers) and data analysis software.
  • Experience with coding and running bioinformatics scripts (Python, numpy, scipy, pandas, jupyter).
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