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Senior Research Associate, Synthetic Biology

Employer
National Resilience
Location
La Jolla, California, US
Salary
Competitive
Closing date
Dec 1, 2021

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Sector
Academic / Research
Field
Informatics / GIS
Discipline
Genetics, Biology
Salary Type
Salary
Employment Type
Full time
Position Summary

This role will be responsible for designing, performing, analyzing, and documenting experiments to support genome engineering research within Resilience R&D. They will work closely to assist scientists and engineers to develop and test workflows and hypotheses. The ideal candidate will have a proven track record of successfully carrying out laboratory SOPs independently. This role requires excellent verbal and written communication.

Job Responsibilities

  • Working with scientists and engineers, design knock-outs, knock-ins, and screening approaches to understand cell biology.
  • Track new techniques and technologies in the field of new nuclease designs and optimization (i.e. Base editing, Prime editing)
  • Prepare presentations and present scientific topics and experimental methods you are working on.
  • Help develop and pilot new laboratory protocols and standard operating procedures with the research team.
  • Maintain clear documentation of experimental setup, reagents used, and data generated using best practices and electronic laboratory notebooks.
  • Assist in organzing electronic laboratory notebook (ELN) contents and laboratory information management systems (LIMS)contents.
  • Perform routine laboratory operations: order and organize laboratory supplies, coordinate cell line management, dispose of dispose of biological and chemical waste; track research team laboratory trainings;
  • Participate in daily Agile stand-ups and weekly sprints with other members of the research team.


Qualifications

  • B.S or M.S. in a biology-related field (e.g. molecular biology, genetics, synthetic biology, immunology, bioengineering).
  • 0-2 years of wet lab experience including operating scientific instrumentation such as thermocyclers, fluorescent microscopes, and gel electrophoresis systems.
  • Significant experience in bacterial and mammalian cell culture systems and trained in aseptic technique.


Preferred Experience

  • Experience with CRISPR systems, experimental protocols, and genotyping analysis methods
  • Ability to use single cell phenotyping technologies (e.g. flow cytometry / FACS-based analysis)
  • Hands-on lab knowledge and experience with current and next-gen genome engineering and sequencing technologies
  • Knowledge of and experience with molecular biology and/or synthetic biology experimental approaches
  • Experience in designing DNA and RNA sequences (plasmids and maps, primers, guide RNA, siRNA).
  • Experience in interfacing with laboratory automation (e.g. automated liquid handlers) and data analysis software.
  • Experience with coding and running bioinformatics scripts (Python, numpy, scipy, pandas, jupyter).

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