Research Associate, Chemical Biology

Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Our lead program targets both the activated and inactive forms of KRASG12C, a validated driver in a number of cancers that until recently has been undruggable. Our pipeline embodies our vision of boldly advancing science to defeat disease, starting with cancer.

Frontier medicines is seeking a highly motivated individual to fill the position of Research Associate/Senior Research Associate in the Chemical Biology team at our Boston location. The successful candidate is expected to have an excellent working knowledge of cell biology and high-throughput screening techniques. This position requires working as part of a multidisciplinary team in a fast-paced drug-hunting environment.

Key Responsibilities

• Contribute to hit identification and validation to ensure the development of a robust preclinical pipeline of impactful drug discovery programs.
• Contribute to project teams and the preclinical development of lead assets to achieve project deliverables.
• Effectively communicate with colleagues and stakeholders; create and present research updates and provide scientific input to team/company meetings.
• Maintain a clear, detailed electronic laboratory notebook to document all experiments and findings.
• Creation of cell lines containing mutant or tagged forms of proteins on various promoters (e.g. native and dox-inducible)
• Cell culture for plate-based screening including viability assessment drug-treatment

Qualifications

• Required
• BS or MS in a biological science (biochemistry, molecular biology, cellular biology or related discipline).
• Mammalian cell culture experience and associated technologies (knockdown, over-expression studies).
• Experience with cellular and biochemical techniques such as luciferase assays, western blotting, and immunofluorescence/histochemistry.
• Familiarity with siRNA and Crispr genetic perturbation methods
• Experience with automation and liquid handling devices e.g. Echo
• Incorporation of heavy metabolites and amino acids for pulse-chase type investigations and use of other custom cell-media formulations
• Experience with patient derived cells, IPSCs, and 3D organoids a plus.
• Excellent communication, organization, and technical writing skills.
• Strong problem-solving skills, ability to learn new skills.
• Legally authorized to work in the U.S.

• Preferred
• 3-5 years of relevant post-graduate and pharma/biotech experience.
• Demonstrated track record of accomplishments and publications in biology.

*Job title will be determined based on experience.

To apply, please send your resume to careers@frontiermeds.com.