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Principal Scientist, Molecular Biology

Confluence Discovery Technologies
Saint Louis County, Missouri, US
Closing date
Oct 23, 2021

View more

Academic / Research
Conservation science
Biology, Grant Writing
Salary Type
Employment Type
Full time
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Position Summary:

The Principal Scientist, Molecular Biology is an independent drug discovery scientist who focuses on the design and execution of projects in their area of expertise. This position will emphasize molecular biology skills for biological, immunological, or other pharmacological analysis in the context of drug discovery. In this position, you will drive focused internal and contract drug discovery and biological research as part of a team of scientists, addressing complex scientific questions in a fluid team environment. Efficient and effective execution is critical.


Essential Duties and Responsibilities:

This position will primarily provide molecular biology support for Cell Biology, Immunology and/or Pharmacology. Broad cell biology expertise will also be expected. Essential roles, responsibilities, and activities a candidate may expect to assume in this position are listed below:

Technology and/or project leadership for internal and/or external projects

Strategy, planning and execution of biologic research studies

Independently develop and validate assays and models including automation and execution

Effective data analysis, interpretation, and impact planning

Quantitative and qualitative analysis

Development of project plans and effective participation in SOW generation and execution

Coordinate equipment and supply needs/purchases

Grant writing, manuscript preparation and external presentation

Presentations and report writing both internal and with customers and other stake holders


Required Education and Experience:

Ph.D. with 2+ years' experience or B.S./M.S. scientist with 8+ years relevant drug discovery experience

Required Knowledge, Skills, Abilities & Behaviors:

Deep understanding of molecular biology methodologies and basic cell biology and immunology.

Preferred molecular biology skills include RNA extraction and qPCR, gene knock-in and knock-out, siRNA, shRNA, transient and stable transfections, use of lentivirus and baculovirus, CRISPR, and nucleofection

Preferred cell biology and immunology skills include expertise in cell and tissue culture techniques, immune cell isolation, cell activation, and measuring molecular and phenotypic responses

Preferred pharmacology skills include an understanding of drug dosing, pharmacokinetics and pharmacodynamics, and ADME. Animal handling experience is not expected

Ability to independently design, develop and execute new approaches and effectively apply traditional approaches to drug design and biological analysis

Viewed as an emerging expert in field of study

Work across lines, interface effectively with project teams, chemistry leadership, company management and customers

Effectively communicate complex data and concepts to the broader organization

Ability to effectively function in a fast paced, challenging, multidisciplinary team environment

The safety and well-being of our employees during the pandemic has been and continues to be a top priority. Toward that end, and based on the latest recommendations of scientists and health officials that the COVID-19 vaccine provides the best protection against severe infection, we are requiring that all successful applicants for open positions at all of our office locations must be fully vaccinated against COVID-19 as a condition of employment. Accommodations may be made in accordance with applicable law.
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