Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through the targeting of beta-propeller domain proteins. Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases. Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Instituteand Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients. We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer. If you are an accomplished life sciences professional that can bring significant energy, passion, and expertise to the team, we welcome the opportunity to consider you for a position. The position. We are seeking an experienced and creative Computational Biologist to help us discover small molecule modulators of beta-propeller proteins, to support validation of new targets, and to help propel our ongoing drug discovery programs.This is an excellent opportunity for individuals looking to work in a fast-paced, dynamic biotech environment.
Responsibilities Contribute to the identification and validation of novel disease targets by mining genomic, protein, structure, and disease databases Build interactive dashboards to promote data accessibility and communicate complex results Biologically curious to develop new hypotheses and perform custom analyses designed to answer biological and translational questions (E.g., patient selection/stratification, biomarker strategy, indication expansion)Apply and develop machine learning and AI methods to enhance discovery effortsIdentify informatics opportunities, propose solutions to support discovery needs Work with chemists, biologists, and protein sciences to integrate experimental data into our growing knowledge base
Qualifications PhD in Bioinformatics, computational biology, computer science, or related field; or MS with equivalent experienceExpertise in multi-omics data analysisProficient in R, or python, and AWS cloud computing fundamentalsKnowledge and application of machine learning techniquesExperience in data modeling and engineering in context of life science drug discoveryExcellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, CROs, and scientific advisorsHighly organized with excellent analytical, documentation and multi-tasking skillsEnthusiastic, self-motivated individual wanting to work in the fast-paced and dynamic environment of a startupCivetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to firstname.lastname@example.org, and we will contact you if needed.CTx1107PM18#LI-DNI