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Director/Senior Director of Biology, Aro Biotherapeutics

Employer
The Higgins Group, Inc.
Location
Philadelphia County, Pennsylvania, US
Salary
Competitive
Closing date
Oct 20, 2021
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Company Overview

Aro Biotherapeutics is pioneering the development of tissue-targeted genetic medicines with a platform based on a proprietary protein technology called Centyrins. The Company is developing a wholly owned pipeline of Centyrin-based therapeutic candidates and is working with industry partners to leverage Centyrins for tissue-specific targeting of therapeutics for a diverse set of diseases. In early 2021, the Company completed one of the largest Series A financings in Philadelphia for a life sciences company.

The Position

Aro Biotherapeutics is building a growing Biology team to identify and characterize novel Centyrin-based therapeutics. This is an exciting opportunity to join the company and play a key role progressing the first Centyrin-siRNA drug candidate to the clinic and expand the applications for Centyrin-oligonucleotide conjugates. The candidate will be responsible for managing the biology activities for our muscle and cardiovascular programs, including efforts to bring a molecule to the clinic as part of a larger cross functional team. Responsibilities will also include defining the long-term strategy for muscle and cardiovascular diseases.

Reporting into the Senior Vice President of Discovery and Translational Research, the new Director/Senior Director of Biology will be a pivotal member of a dynamic team committed to creating a new class of transformative medicines for patients. This is a leadership position with responsibility for a team of scientists and requires team-oriented and positive "can-do" attitude.

Responsibilities

* Manage discovery activities for lead molecule and future metabolic/muscle/cardiovascular programs
* Provide support as a key member of a cross functional team to bring a Centyrin:siRNA conjugate to the clinic including activities required for IND submission
* Provide strategic guidance to the leadership team around metabolic, muscle and cardiovascular diseases
* Oversee the design and execution of in vivo pharmacology studies to assess drug candidates
* Regularly present work to internal project teams and R&D Leadership
* Manage an existing and growing team of scientists and investigators
* Hands on benchwork not required but acceptable
* Comply with laboratory safety procedures and maintain compliant laboratory records of experiments
* The candidate will need to work onsite at least 80% of the workweek
* Experience with designing and operationalizing early clinical trials, ideally with programs focused on neuromuscular diseases and/or immune mediated diseases

Qualifications

The ideal candidate for this position will bring possess strong leadership, management, and communication skills. Aro is building a culture rooted in flexibility and adaptability. The Company is doing incredibly novel work and a roll-up-the-sleeves and open-minded mindset are required.

* PhD in biological sciences, with >7 years of experience in pharma or biotech
* Understanding of the fundamentals of drug discovery and development
* Experienced in molecular and cell biology; understanding of metabolic diseases is a plus
* Proficiency in the independent design and analysis of experiments. Significant understanding of data analysis, reproducibility, and reliability of experimental data
* Demonstrated ability to work effectively in a matrixed and highly collaborative team
* Demonstrated management experience of both scientists and Ph.D.s
* Strong communication skills, both written and oral with an ability to organize and communicate complex data sets in a clear and concise manner
* Experience authoring peer-reviewed scientific publications and presenting at scientific conferences
* Proven track record of being personable, energetic, responsive, action-oriented, and accountable
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