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Scientist / Senior Scientist - Yeast Synthetic Biology

New York, Iowa, US
Closing date
Oct 18, 2021

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Consultancy/Private Sector
Informatics / GIS
Genetics, Biology
Salary Type
Employment Type
Full time
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Job Description
Title: Scientist/Senior Scientist, Yeast Synthetic Biology

Reports to: Team Lead, Yeast Synthetic Biology

About Us

Neochromosome, Inc. (part of Opentrons) is a biotech startup whose disruptive chromosome synthesis and engineering technologies are changing the world of synthetic biology. Rather than piecemeal editing of an existing genome, Neo delivers entire chromosomes designed de novo to be modular and orthogonal to the host cell. Neo's work has revolutionized the Design - Build - Deliver paradigm for biological engineering with a focus on higher eukaryotic cells for expression of commercially valuable biological pathways.

Neo's team has highly unique experience building the world's first synthetic eukaryotic genome for the Sc2.0 project, and with the backing of Opentrons automation and engineering, is working to unlock the next generation of synthetic biology applications.

About the role:

As a member of the Yeast Synthetic Biology Team, the candidate will work with a team of S. cerevisiae geneticists and biologists to execute on audaciously large-scale yeast genome manipulation projects. The role will involve establishing and implementing repeatable and scalable workflows with the support of automation to execute against aggressive project deadlines. The candidate will be responsible for managing technicians within the team. The Yeast Synthetic Biology Team will work alongside a dynamic group of scientists, product managers, and software and automation engineers who are part of the Design and Synthetic Biology Foundry teams to drive successful next-gen cell product development.

  • Develop and implement optimized workflows for large-scale yeast genome manipulation projects, leveraging automation where appropriate.
  • Manage and mentor technicians within the team to achieve project success.
  • Execute against milestones to deliver on time or ahead of time results .
  • Participate in evaluating and refining lab workflows and interface with process, software and automation engineers to ensure process optimization.
  • Participate in quantifying and communicating results of the team within the organization via presentations and written reports.
  • Maintain world-leading knowledge in the field of synthetic biology.
  • Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

Basic qualifications:
  • PhD in genetics, molecular biology, biotechnology, biology, bioinformatics, bioengineering, or related field.
  • Deep expertise in yeast genetics and genome manipulation gained through at least 3 years of hands-on experience working with S. cerevisiae in the lab.
  • Demonstrated ability to work in the context of a multidisciplinary team.
  • Great analytical skills and a logical approach to problem solving.
  • Strong communication skills, both written and oral.
  • Ability to execute and thrive in a dynamic startup environment.

Advanced qualifications:
  • Postdoctoral experience working in yeast genetics and/or synthetic biology
  • Experience working with long synthetic DNA molecules.
  • Experience with large-scale screening experiments using S. cerevisiae (e.g. SGA)
  • Previous experience implementing lab automation workflows to enable high throughput experiments.
  • Experience debugging complex synthetic systems.

About Opentrons

Currently, over 90% of biologists in the world run experiments with manual pipettes, moving tiny amounts of liquid from vial to vial by hand. That's why Opentrons makes robots for biologists that are 10x cheaper and easier to use than any lab automation before. Our robots automate experiments that would otherwise be done by hand so our users can spend less time pipetting and more time pursuing answers to the 21st century's most important questions.

Opentrons' robotics are in use in over 40 countries around the world and have been adopted by top-tier institutions like Stanford, Harvard, Merck, and Roche. Opentrons is VC-backed with investors including Khosla Ventures, Lerer Hippeau Ventures, and Y Combinator.

Opentrons is an equal opportunity employer and does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy and gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service, or other non-merit factor.

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