Senior Scientist, Protein & Structural Biology

Senior Scientist, Protein & Structural Biology

Location: Waltham, MA

HireMinds is exclusively representing a pre-Series A biotech that is seeking to build their drug discovery team. This team needs your expertise in protein sciences and structural biology to support cutting-edge small-molecule lead discovery efforts. In this role you will work with devising structural biology efforts and carry out experiments with CROs in the execution of X-Ray Crystallographic studies and cryo-EM for projects in oncology focus. You will also work to develop in-house efforts with protein expression and purification strategies to support and enable lead finding and optimization studies. If this is the right next step for your career contact the HireMinds Life Sciences & Biotech team to learn more.

In This Role You Will:

• Develop strategies for large-scale recombinant production of proteins and protein complexes to support assay development, high-throughput screening, and structural biology efforts
• Provide X-ray crystallographic support to determine structures of novel complexes
• Build an internal knowledge base around certain protein classes of interest
• Provide expertise with cryo-EM technologies and conduct studies with CROs in relation to binding-assays or characterization studies
• Interface with external CRO partners and internal Biology and Biochemistry team members to understand project needs, deliverables, and timelines

In This Role You Will Bring:

• PhD in Structural Biology, Biophysics, Protein Biochemistry or related fields with 0-5 years of industry experience or MS with ~6 years experience
• Expertise in construct design for expression in bacteria, insect cells, and/or mammalian cell cultures and further purification strategies/activities
• Track-record of executing crystal trials and solving novel structures of proteins, protein-ligand or protein-protein complexes
• Ability to collaborate with peers in lead finding focused on biochemical and biophysical assays used in small-molecule drug discovery and understand basic concepts
• Attention to detail and proven track record in handling, analyzing, and presenting experimental data to drive Go/No-Go decision making
• Collaborative team-first mentality with ability to contribute to teams expertise with Structural Biology
• Ability to work in a fast-paced biotech environment and adapt to changing demands