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Senior Scientist - Molecular/Cellular Biology

Design Therapeutics
Carlsbad, California, US
Closing date
Oct 14, 2021

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Job Description
This scientist will be a key member of the Design team responsible for driving early-stage discovery efforts in new disease areas. This will include designing and implementing biochemical and cellular assays for assessing GeneTAC efficacy. This position will collaborate closely with colleagues working on compound design and in vivo performance. Core technologies used include tissue culture of primary and differentiated cells relevant to the disease, molecular characterization of gene expression and chromatin marks, and cytology. In addition to designing, conducting, and interpreting experiments, the successful candidate will help identify new areas for discovery research, be a member of cross functional teams that set program strategy, objectives, and project plans, and manage work with outside collaborators.
  • Develop and conduct biochemical, cellular, and biophysical assays to support research and lead optimization campaigns.
  • Build and conduct assays that answer key underlying mechanistic questions and activity of GeneTAC molecules
  • Develop expertise in new disease and technical areas by reading literature and consulting with outside experts
  • Independently develop technical science plans including development and deployment of new technical approaches
  • Collaborate with clinical and academic partners
  • Contribute to cross functional project teams responsible for drug development, from target selection to lead identification to ongoing development
  • Management of Research Associate(s)

Education, Experience & Skills Requirements:
  • Ph. D. in relevant field and post-doctoral experience
  • Hands-on experience in developing molecular methods, ideally with experience in NGS and RT-qPCR
  • Experience in cell culture, ideally including iPSC experience
  • Experience developing or implementing new assays
  • Hands-on experience in wide variety of cell biology techniques, e.g., immunohistology, FISH, NanoBRET, etc.
  • Willingness to learn and support in vivo experiments as needed.
  • Demonstrated ability to problem solve and multitask in a fast-paced biotech environment
  • Effective oral and written communications
  • Currently authorized to work in the U.S.
Company DescriptionDesign Therapeutics is a biotechnology company developing a new class of genomic medicines based on our platform of gene targeted chimera (GeneTAC TM) small molecules. GeneTAC molecules are designed to either turn-on or turn-off specific disease-causing genes to address the underlying cause of disease. The company's lead program is focused on the treatment of Friedreich ataxia, followed by a program in myotonic dystrophy type-1 and discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions.
We are a group of passionate and experienced drug developers based in Carlsbad, California and since our inception in 2017 we have raised over $400 million from leading healthcare investors. Following our successful IPO in March 2021 we are advancing our lead programs and expanding our pipeline.
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