Glial Biology Senior Associate Scientist

Employer
Biogen
Location
Cambridge, Massachusetts, US
Salary
Competitive
Closing date
Oct 24, 2021

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Company Description

At Biogen, we offer a workplace that is unique, connected, resilient and impactful. Our purpose to find cures for rare diseases is a unique focus within our industry. We are connected as a team by this shared purpose, the pride we have in our work, and the inspiration we obtain from the lives we're changing. We are resilient as we overcome obstacles, following the science to deliver for our patients. Most of all, our work allows us to have an impact. An impact on our patients' lives and on changing the course of medicine.

Job Description

About This Role

The Biogen Alzheimer's Disease Research Unit is driving innovation on early drug discovery and laying the translational framework for novel mechanisms to be brought forward into clinical interrogation. Our mission is to focus on the strength of human biological evidence in order to one day transform the way we treat neurological diseases and their progression. We are looking for an innovative, enthusiastic, and dedicated research scientist to join our team and contribute to the generation of pioneering therapeutics.

The ideal candidate would be a biologist with expertise working in immune or glial cells, strong general molecular biology skills, a background in pharmacology, experience developing functional or high-content imaging assays, expertise in de novo assay development principles, and a general understanding of the drug discovery to early development process. This role represents your opportunity to apply your current knowledge to on-going discovery programs, helping to further connect pharmacological mechanism of action with cellular proof-of-biology and in vivo pharmacodynamics. We welcome candidates who share our passion to advance novel therapeutic mechanisms from target discovery to early clinical development.

The Associate Scientist 3/Senior Associate Scientist will be expected to take innovative approaches to novel assay development and balance this approach with a scientifically rigorous mindset to drive optimization and program impact. As a qualified scientist, you will be expected to work independently toward objectives but frequently communicate results to project leaders and collaborators. While you are able to solve complex problems individually and exhibit technical expertise, you recognize the benefit of working with others toward your goals and helping others toward shared objectives. You will therefore be supported by and contributing to a team-focused environment.

What You'll Do
  • Investigate, develop and implement new biochemical assays from cells, preclinical models, and human tissue to advance priority pipeline programs
  • Develop functional assays in iPSC-derived/primary microglial (highest-priority), neuronal and astrocyte systems to better understand the genetic underpinnings of Alzheimer's disease risk/resilience associated genetic targets, polymorphisms and their related biological pathways
  • Apply various genetic engineering approaches to support target validation efforts
  • Leverage a combination of biochemical approaches, combined with high-content/resolution microscopy to characterize cellular models of astrocyte and microglia biology
  • Establish SOPs and adapt new protocols from literature
  • Maintain electronic laboratory notebooks and present data to the team
Who You Are

You are passionate about drug discovery, have a strong intrinsic drive to make a difference, maintain a commitment to scientific quality, and use your curiosity and rigor to drive forward discovery research and development. You are a forward-thinker, motivated to learn new skills, ask questions, always consider the most direct path to your work, and are a team player who strives to foster an inquisitive, inclusive, and impactful work environment

Qualifications

Required Skills
  • Master's degree in neuroimmunology, cell/molecular biology, biochemistry, or chemical biology
  • Prior experience in drug discovery R&D for neurodegeneration
  • Expertise working with primary rodent glial and neuron cultures, as well as iPSC derived model systems, as applied to target discovery, validation, and cellular proof-of-action
  • Extensive knowledge of various genetic delivery (plasmid and viral) and disruption (Crispr and RNAi) techniques
  • Broad hands-on experience with various gene expression, immunoassay, and molecular profiling approaches applied to cells and brain tissues
  • Strong skillset in the development robust and reproducible imaging-based cell functional assays
  • Ability to independently design, execute, and analyze experiments
  • Strong critical thinking, communication, organization, and presentation skills
Preferred Skills
  • Research experience in neurological disorders
  • Prior experience with multi-omic profiling - proteomics and transcriptomics
  • Prior experience with confocal or light-sheet microscopy
Additional Information

Why Biogen?

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients' lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.

All your information will be kept confidential according to EEO guidelines.

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