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Director, Translational Biology

Employer
Exo Therapeutics
Location
Watertown, Massachusetts, US
Salary
Competitive
Closing date
Oct 14, 2021

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EXO Therapeutics

Director, Translational Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company's ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company's team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Position Overview

Exo Therapeutics seeks a strong leader to oversee our translational biology efforts and provide strategic and technical expertise for Exo's research portfolio. You will be an integral part of the biology leadership team, working cross functionally to drive cutting-edge research for disease indications and biomarker studies - with an initial focus in immunology and/or oncology. You will be responsible for making decisions, but also be comfortable rolling up your sleeves and contributing hands-on with the team. You will have the opportunity to drive the design and execution of experiments with key collaborators and outside contract organizations and have highly visible opportunities to interface with all levels of our organization to deliver scientific excellence, as we expand the boundaries of research for patients.

Responsibilities
  • Provide strategic, scientific, and managerial leadership to build and drive the translational biology efforts
  • Oversee identification and validation of biological contexts, in vitro and in vivo, that create a dependency of drug targets to aid indication/ context prioritization for pre-clinical studies and clinical development
  • Define, oversee, and lead biomarker strategy to enable progression from preclinical to clinical studies in collaboration with colleagues in research, clinical development, and clinical operations departments
  • Develop program specific translational strategies that integrate preclinical research findings
  • Serve as translational lead (directly and/or indirectly) for multidisciplinary drug discovery project teams in a fast-paced, results-driven biotech environment
  • Collaborate with drug discovery and clinical teams to select disease indications and combination strategies for inflammation and/or oncology targets
  • Define biomarker assays that assess drug pharmacodynamics and allow testing of preclinical response hypotheses enabling a differentiating path for drug development
  • Manage relationships with external KOLs aimed at gaining better understanding of patient stratification, combination studies and PD biomarkers


Required Qualifications
  • Ph.D. with 10+ years of experience in biology, with 7+ years in biotech/ pharmaceutical industry
  • Experience leading translational biology efforts on project teams at various stages of the programs
  • Strong understanding of inflammation/ autoimmunity/ cancer cell signaling pathways and experience with PK/PD/efficacy studies to validate disease indications
  • A strong track record of success in delivering clinical candidates
  • Experience with Small molecule drug development and IND submissions
  • Experience with selection and development of in vivo disease models
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.
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