Sr. Director, Biology

Foghorn Therapeutics
Cambridge, Massachusetts, US
Closing date
Oct 26, 2021

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Foghorn Therapeutics is pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, an untapped opportunity for therapeutic intervention. Our proprietary Gene Traffic Control® platform gives us an integrated, mechanistic understanding of how the various components of the chromatin regulatory system interact, allowing us to identify, validate and potentially drug targets within the system. The Company, currently in pre-clinical stage, is advancing over 10 small molecule and protein degrader programs across a wide range of cancers.

Foghorn was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at .

About the Chromatin Regulatory System

The chromatin regulatory system regulates gene expression by directing the movement of molecules that turn genes on and off. Disease dependencies associated with the chromatin regulatory system are estimated to impact over 2.5 million cancer patients across the United States, Europe and Japan. This system is further implicated in neurological, autoimmune, and other serious diseases.

Job Summary

Foghorn Therapeutics has been successful in validating our Gene Traffic Control platform by bringing two molecules into clinical development. We are now looking to capitalize of that success by investing heavily in the exciting portfolio of earlier stage assets that are underway. We are currently seeking a highly motivated, innovative, and collaborative PhD or MD/PhD Oncology Biologist to lead target and drug discovery efforts in a variety of oncology indications. You will be inspired and driven to discover and develop treatments for patients with serious unmet medical needs. The successful candidate will also demonstrate a record of achievement in developing small molecule therapeutics.

This position will report to the Head of Biology and in addition to leading a team of biologists , will partner with key stakeholders in Immunology Biology, Chemistry, Drug Discovery, and Clinical Development to discover and develop target hypotheses utilizing the industry leading Gene Traffic Control platform developed at Foghorn. The successful candidate will be an important member of the biology leadership team and in addition to delivering exciting pipeline assets, will help build the forward-looking scientific vision of the company.

Key Responsibilities
  • Provide team leadership and/or team leader mentorship to guide the execution of scientific team and project initiatives
  • Guide research strategy and experimentation in both preclinical and clinical research programs
  • Advance research programs from early target ID and validation to IND enabling studies
  • Coordinate project team activities and efficiently drive execution of Foghorn's drug discovery programs and company goals
  • Lead interactions with key opinion leaders and the external research community
  • Represent the company at external scientific meetings
  • Supervise and mentor career development of scientists in the biology team

  • Ph.D. or equivalent in Biology, Translational Science, Oncology, or related field
  • More than 10 years of industry experience in small molecule target identification and drug discovery
  • Experience leading teams at various stages of small molecule drug discovery
  • Research experience in transcription and chromatin biology is a plus
  • Proven leadership skills and a desire to mentor early-career scientists
  • Strong communication skills and ability to work effectively across functions
  • Extensive experience in managing CROs is highly desired
  • Hands-on mentality and the ability to focus on details in moving projects forward
  • Ability to think critically and creatively in a fast-paced research environment
  • Willingness to work in an innovative and collaborative environment pursuing high risk-high reward science
  • Adaptability, commitment to scientific excellence, and team member mentality is a must

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