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New Product Development, Assays and Assay Systems, Computational Biologist

San Jose, California, US
Closing date
Sep 29, 2021

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Consultancy/Private Sector
Informatics / GIS, Development
Salary Type
Employment Type
Full time
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Acuity Spatial Genomics, Inc. (a Bruker subsidiary) is focused on opening a new frontier in spatial 3D genomics and multiomic analyses. We are committed to the development of a novel technology platform allowing progress in genome-wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. The Company brings together the premier spatial omics approach (OligoFISSEQTM) with leading-edge imaging, data acquisition and analysis capability. The pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single cell and sub-cellular level. We aim to find the best talent in the field to join and contribute to this extraordinary, exciting endeavor becoming a critical member of this groundbreaking opportunity.

Position description:

The candidate will be a key contributor to the design and deployment of a suite of targeted panels for 3D genomic chromosome and chromatin architecture as well as the owner and developer of an assay design pipeline.

The candidate will aggregate information from multiple scientific sources and lead the design of targeted panels and collaborate with assay developers to deploy these panels as products

The ideal candidate should have experience working independently in a biochemistry or molecular biology assay development environment, have exceptional attention to detail, and be able to critically analyze data and communicate results to the team. They must bring a can-do attitude and sense of purpose to the job. This position must be able to independently make decisions on work direction.


Develop a deep understanding of the available scientific literature describing potential targets for spatial genomic analysis and lead in development of a methodology to convert these into assay targets.

Independently optimize the assay design pipeline and develop systems to maintain revision control of the pipeline and assay designs.

Work within multidisciplinary teams at all stages of product development.

Work with assay developers to test and optimize the assay design pipeline.

Prepare internal and customer-facing technical documentation including summaries of criteria governing choice of targets and panel designs.


BS in chemistry, biochemistry, molecular biology, genetics, bioinformatics, computational/systems, computer science, biology physics or similar.

2-5 years relevant laboratory or industry experience in life science applications, such as design of assay panels for PCR, NGS or In-situ hybridization.

Proven track record in handling of large data/information sets through use of databases and developing analysis workflows in programming languages such as R, python, and MATLAB to extract and parse genomic information.

Familiarity with genomics data formats (FASTA, FASTQ, etc.) and UCSC genome browser.

Familiarity with Bowtie2, NUPACK, BLAST and other genome alignment software.

Ability to quickly analyze and interpret complex datasets and communicate results in a clear and concise manner.

Demonstrated ability to work in a multi-disciplinary team.

Thorough understanding of statistical analysis tools.

Experience troubleshooting and optimizing molecular biology assays.

Additional desirable skills to have:

Experience with new product introduction or product development process and life cycle.

Experience with advanced fluorescence techniques and multi omic microscopy image analysis.

Experience with NGS analysis.

Experience in assay development on novel and prototype instrumentation and workflows.

The Company offers a comprehensive and competitive benefits package including medical, dental, 401(k), paid vacation, holidays, and tuition assistance (as applicable).

We are an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, veteran status, and other protected characteristics.

Certain positions at the Company require compliance with export control laws and a result, all interviewed candidates for all positions will be screened pre-interview to determine their eligibility in light of export control restrictions."

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