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Senior Research Associate, Cell Biology

Employer
Civetta Therapeutics
Location
Cambridge, Massachusetts, US
Salary
Competitive
Closing date
Oct 6, 2021

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Job DescriptionLocation: US-MA-Cambridge
ID: 2021-1576
# of Openings : 1
Category: Research & Development
Address: 10 Wilson Road

Overview

Overview

Civetta Therapeutics (located in Cambridge, MA) is developing novel therapeutics through the targeting of beta-propeller domain proteins. Beta-propellers are a class of highly conserved structural proteins that are implicated in a range of indications, including multiple types of cancer, neurodegenerative and metabolic diseases. Backed by Deerfield Management, Civetta was founded by William Sellers (Broad Institute and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber Cancer Institute and Harvard Medical School) with the mission to leverage the wide array of biologic functions in which propeller proteins participate to discover impactful new medicines for patients.

We are building a team of talented, dedicated scientists who share our vision and our passion to discover groundbreaking new drugs to treat some of the most difficult diseases, including cancer. If you are an accomplished life sciences professional that can bring significant energy, passion and expertise to the team, we welcome the opportunity to consider you for a position.

The position. We are seeking a motivated and technically experienced Senior Research Associate to help support our cell biology efforts at Civetta. This candidate will help us discover small molecule modulators of beta-propeller proteins, support validation of new targets, and help propel our ongoing drug discovery programs. This is an excellent opportunity for individuals looking to work in a fast-paced, dynamic biotech environment.

Responsibilities

Responsibilities
  • Build and execute cell-based assays to support drug discovery campaigns and mechanism- of-action studies
  • Support the establishment of engineered cell lines using a variety of techniques (CRISPR endogenous gene editing, over-expression, knock-down and knock-out)
  • Execute a wide variety of cellular and molecular techniques to validate and characterize genetic or small molecule perturbations of targets and downstream pathways, such as CRISPR/RNAi tool design/generation, Western blot, qPCR, ELISA, immunoprecipitations, luminescence assays, and phenotypic assays)
  • Collaborate with colleagues in chemistry, biochemistry/biophysics, and structural biology to evaluate and advance chemical matter for programs and platform efforts
  • Design and conduct well controlled high-quality scientific experiments to test biological hypotheses
  • Contribute to evaluation and development of new approaches and technologies within the biology group
  • Maintain an electronic lab notebook in compliance with company policies.
  • Help establish the biology group and contribute to building a culture that embraces continuous learning and improvement


Qualifications

Qualifications
  • BS with 5+ years of relevant industry experience; or MS with a minimum of 3+ years of relevant industry experience. Degree must be in Biology, Molecular Biology, Biochemistry, or related Life Science discipline
  • Extensive tissue culture experience with suspension and adherent cell lines with outstanding aseptic technique
  • Experience working with protein interactions and multi-protein complexes, specifically co-immunoprecipitations of proteins
  • Experience with protein (e.g. Western blotting, ELISA) and RNA (RT-qPCR) analysis techniques and cell viability/cell death assays
  • Experience working with small molecule compounds using liquid handling and lab automation is highly desired
  • Knowledge of instrumentation such gel-imaging systems, automated/digital liquid dispensers (e.g. Multidrop combi). Experience with live cell analysis systems (e.g. Incucyte) is also a plus
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, CROs, and scientific advisors
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Enthusiastic, self-motivated individual wanting to work in the fast-paced and dynamic environment of a startup


Civetta Therapeutics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

Notice to Third-Party Recruiters/Staffing Agencies: Recruitment is managed through Civetta Therapeutics' Human Resources department. Resumes will only be accepted from staffing agency/recruiters if there is a signed contract in place. Recruiters are requested to not contact our hiring managers or employees directly to inquire about open positions or to present candidates. In the event a staffing agency/third-party recruiter submits a resume without a contract in place, the candidate submitted will be considered unsolicited and treated as if the candidate submitted their resume directly to Civetta, and no fee/payment will be paid. Recruiters interested in working with Civetta Therapeutics can submit their information to contact@civettatherapeutics.com, and we will contact you if needed.

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