At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.Position Summary:
Senior Associate Scientist, Cancer Biology (non-PhD)
We are seeking a Senior Associate Scientist to join the Cancer Biology research team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, CA. The qualified candidate will aid in the advancement of early-stage therapeutic targets at the intersection of tumor genetics and immuno-biology. The Cancer Biology team is composed of experts in tumor-intrinsic biology, functional genomics, and immune-oncology who work closely with immuno-oncologists and stroma biologists to develop therapeutic targets integrated across the tumor microenvironment. Our mission is to provide transformative therapeutics to cancer patients that improve response rates and durability to this challenging disease.
The qualified candidate is a motivated, interactive, and creative biologist possessing the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the oncology, immuno-oncology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.Qualifications
- B.S./M.S. in biology or related field with 5+ years of experience in cancer biology, immuno-oncology, or cellular and molecular biology is required. 2+ years of industrial scientific experience preferred.
- Demonstrated independence in experimental design, execution, data analysis and troubleshooting are required.
- Required technical expertise:
- Cell culture: cancer cell line propagation and qualification, BSL2+ and lentiviral production/transduction highly desired.
- Molecular biology: cloning, nucleic acid sequence analysis, PCR, primer design, gene synthesis (outsourced), electroporation.
- mRNA analysis: cDNA synthesis, RNA quantification, Taqman qPCR
- CRISPR/Cas9/sgRNA/RNAi: design, cloning, and implementation of stable knock-in/knock-out experiments in cell lines using transfection and lentiviral delivery. Hands-on functional genomics experience is desired.
- Protein characterization: western blotting, immunoprecipitation, immunofluorescence, fluorescence microscopy.
- Plate based assays: CTG and IncuCyte. Knowledge of or exposure to assays to identify and optimize drug candidates is desired.
- Computation: proficiency in GraphPad Prism, FlowJo, Microsoft Office etc. for data analysis and figure generation is required. Experience in data mining through use of desktop tools/interfaces and public databases (e.g., UCSC genome Browser, cBIO, GTex, Depmap) is highly desired.
- Excellent interpersonal skills with the ability to collaborate and interact effectively with colleagues is required.
- Ability to mentor more junior scientists and colleagues on laboratory techniques and best practices is highly valued.
- Attention to detail with excellent organizational and record keeping skills is required.
- This is a laboratory-based position in Redwood City, CA. There will be less than 10% travel.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
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