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Principal Scientist, Stromal Biology Translational Research

Employer
Bristol Myers Squibb
Location
Portola Valley, California, US
Salary
Competitive
Closing date
Sep 20, 2021

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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprised of scientists across multiple disciplines, we are responsible for the biology and translational science necessary to support drug development from target identification through to first-in-human studies.

Position Summary:
We are seeking a highly motivated and experienced individual with translational expertise in stromal biology to join the TME TRC Translational Research team at Bristol Myers Squibb in Redwood City, CA. This individual will lead the translational research efforts for stromal targets in the tumor microenvironment. The successful candidate will work in close collaboration with the Stromal Biology discovery scientists to drive biomarker strategies and identification for early stromal programs. In addition, the Translational Scientist will work collaboratively with the Translational Development team to build the deep, mechanistically driven translational packages that are required to support indication selection, target engagement, and predictive and pharmacodynamic biomarker assays for oncology-focused programs within the TME TRC. As lead of the Stromal Biology Translational Group, you will bring scientific experience in translational research with an emphasis on stromal biomarkers and will have an in-depth knowledge of the steps required to progress a program from preclinical to clinical stage.

Roles and Responsibilities
  • Accountable for establishing the scientific translational research plan for understanding indication selection, target engagement, predictive and pharmacodynamic readouts that can be measured in clinical trials.
  • Accountable for design of hypothesis-driven studies using human samples to inform pharmacodynamics, mechanism of action, and patient stratification/selection including development of relevant ex vivo translational models as needed.
  • Mentor and manage a direct report to develop and execute early translational research plans for the stromal biology programs within the TME TRC portfolio.
  • Partner closely with stromal biology scientists from TME-TRC, bioinformatics, translational research technology experts to leverage any needed resources from additional teams to ensure translational plans are executed on effectively and in a timely manner.
  • Effectively collaborate in highly matrixed organization to drive the advancement of therapeutic candidates.
  • Actively participate in internal and external scientific meetings through presentations and critical evaluation of both internal results and emerging scientific literature.
  • Act as a subject matter expert resource for targeted oncology translational efforts, and train and develop direct reports in translational approaches.
  • Play a key role in providing the relevant translational input to discovery translational projects as part of interdisciplinary teams.


Experience
  • Ph.D. in Cancer Biology, Cell Biology, Immunology or equivalent advanced biology degree.
  • Experienced translational scientist with 5+ years of relevant experience in tumor and stromal biology (including in the industry setting), and a strong background in human systems.
  • Experience in oncology drug discovery and development, with strong understanding of the role of translational research in the drug development process, and expertise in biomarker discovery, biomarker assay development
  • Working knowledge of all functional areas of drug development, including biology, clinical development, and diagnostic development including fit for purpose assay validation principles for clinical assays.
  • Familiarity with biomarker assay development (tumor tissue-based and peripheral immunoassays, genomics, transcriptomics) to guide experimental prioritization.
  • Experience working with human tumor-associated stromal cells, designing and conducting biomarker and/or mechanistic studies and development of ex vivo translational models designed to address key translational hypotheses.
  • Proven track record of handling multiple high priority tasks in parallel with internal and external collaborators including CRO's and academics.
  • Excellent verbal and written communication skills across all levels both within an organization and with external collaborators/companies with the ability to recognize, articulate, and accept calculated risks to make informed decisions.
  • Prior line management experience, experience in mentoring scientists, and a proven ability to build an effective organization by attracting, retaining and developing high-caliber scientists.
  • Comfortable working in a collaborative manner in a fast-paced environment.
  • Willing to work as a topic expert, outside of a traditional functional environment, in a team unified around serving the assets.


BMSONCRD, BMSDDTMRCA

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
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