Associate Scientist / Senior Associate Scientist, Biology (Oncology)

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas' PROTAC Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas' pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes two clinical-stage programs: ARV-110, which is being developed as a potential treatment for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 200 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and purpose - to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It's an exciting time to be in drug development and it's an exciting time to be at Arvinas. But don't just take our word for it - here's what Arvinas employees are saying. For more information, please visit www.arvinas.com.

Position Summary

This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members in order to deliver quality data in support of drug discovery efforts. Data analysis and interpretation is required, as will be method development where appropriate. This position reports to a Senior Research Scientist, Biology and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Design and execute experiments, and perform data analysis
• Utilize compounds and molecular target manipulation (e.g. RNAi) to dissect target function and dependency
• Leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds or target modulation
• Design, QC, validate, and execute medium- to high- throughput 96/384 well assay formats, such as ELISA, quantitative Western, cell viability/death
• Perform molecular techniques including cloning, PCR, RT-PCR, cell line engineering
• Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression
• Document, compile and interpret experimental data; manage laboratory notebook, databases, and/ or spreadsheets to present data in a meaningful manner
• Keep up to date on relevant scientific literature

Qualifications

• In-depth knowledge of cell biology and cancer biology
• Proficient In vitro and or ex vivo tissue culture techniques
• Experience in various cellular functional assays (i.e. 2D/3D cellular proliferation assays/cytotoxicity/apoptosis assays/siRNA/shRNA/CRISPR knockdown assays)
• Experience with development and optimization of cell-based and biochemical assays using a variety of readout technologies (e.g. fluorescence, luminescence, TR-FRET, AlphaLISA)
• Proficiency in various bioassays (e.g. High Quality Western Blots, ELISA, Multiplex Protein Analysis)
• Proficiency in flow cytometry and data analysis is a plus
• Excellent data handling and recording skills as well as oral and written communication skills
• Work as a team player and be able to work on several projects simultaneously
• Ability to work and problem-solve independently while under general supervision by the project leader
• Proficient with Microsoft Excel, PowerPoint, Prism, etc. is required.

Education

• BS/MS in Biology or relevant discipline, or equivalent education and experience with >3 years Pharma/Biotech experience

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness, and financial security of our employees and their families. Benefits include group medical, vision, and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com.

Arvinas is an Equal Opportunity Employer.