Senior Research Associate / Scientist I, Biology (Contract)

Senior Research Associate / Scientist I, Biology (Contract) at Rheos Medicines

Rheos Medicines is a precision medicine company using insights from immunometabolism to bring novel therapeutics to patients suffering from autoimmune diseases. The company's approach elucidates the underlying complexities and heterogeneity of immune mediated disease via a proprietary platform and product engine that integrates multiple "-omic" datasets through a metabolic lens. Rheos systematically defines the biologic links between immune cell metabolism and function across patient subsets and advances novel biomarker-enabled small molecule therapeutics to bring precision to the treatment of immune-mediated diseases. In December 2019, we entered a worldwide collaboration with Roche to identify and develop new therapeutics for autoimmune and inflammatory disease. Rheos was founded by Third Rock Ventures and is located in Cambridge, MA

The Role

We are currently seeking an enthusiastic scientist for the position of Senior Research Associate-Scientist I (40 hours 6 + months) in the Biology team. The successful candidate will make important contributions to our drug discovery and development programs by generating high-quality `omics and immunological data sets from patient samples. The candidate will support biomarker discovery goals within cross functional team settings.

Responsibilities

Execute experiments with patient-derived immune cells, including drug treatments, harvesting of cells and supernatants, preparation of cells for ‘omics platforms, analysis of cells and supernatants using:

· Flow cytometry immunophenotyping of cells

· ELISA of supernatants

· Maintain inventory of patient samples using electronic laboratory notebook and in-house tools. Work with in-house Informatics team to build sample and data processing pipelines.

· Optimize and troubleshoot methods to stimulate patient immune cells.

· Analyze data with established informatics tools.

· Present results to project teams.

· Maintain accurate and detailed electronic scientific notebook.

Requirements

· B.S. with 2+ years lab-based experience or M.S. degree in biology or related field

· General knowledge of and experience performing immunological techniques, including flow cytometry and ELISA.

· Experience handling cells, plasma, tissues, and other biological matrices.

· Ability to understand and follow protocols to perform high-throughput, quantitative bioanalysis.

· Proficiency with data analysis software (Microsoft Office Suite, GraphPad Prism, Spotfire, etc.). Additional bioinformatics skills to analyze big data sets, including exposure to R statistical programming language, is a plus.

· Strong work ethic, good team player, and highly organized.

· Must thrive working in a fast-paced, collaborative environment with effective time-management and communication skills.

Rheos Medicines is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Rheos Medicines complies with applicable state and local laws governing nondiscrimination in employment.

29 Newbury Street
3rd Floor
Boston, MA 02116
P (617) 585-2000