Senior Director/Director Biology

4 days left

Employer
Axcella Health, Inc.
Location
Cambridge, Massachusetts, US
Salary
Competitive
Posted
Sep 06, 2021
Closes
Oct 01, 2021
Ref
2423194421
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Axcella is a clinical-stage biotechnology company pioneering the research and development of novel multi-targeted interventions to treat complex diseases and improve health. Our product candidates are generated from our proprietary, human‑focused development platform and harness the power of endogenous metabolic modulators (EMMs), a broad family of molecules that fundamentally impact and regulate human metabolism.

We are growing quickly as we advance in the clinic, and we are seeking exceptional people to join our team. We value bright minds, collaborative spirits and a willingness to think outside the box.

Axcella Health is seeking a Senior Director to join our dynamic Research Team in Cambridge, MA in a laboratory and discovery program leadership position. In this role s/he will work collaboratively across R&D to develop and advance endogenous metabolic modulator (EMM) candidates through thee discovery pipeline, elucidate mechanisms of action from exploratory clinical studies and studies in primary cell culture, as well as metabolomics/genomics studies. The scientific focus of this role is to lead and inform candidate advancement through non-clinical and clinical development and characterize dysregulated biologies in complex diseases such as Cirrhosis and NAFLD/NASH to build our understanding of how EMMs can impact these biologies. A deep understanding of human metabolism with experience in aspects of cellular energetics is essential, with knowledge of amino acid metabolism highly desirable. The candidate will be expected to thrive in the fast paced, dynamic, and nimble environment of a biotech company that depends on strong collaboration internally (e.g. clinical, clinical pharmacology, computational biology) and externally (e.g. academics and CROs).
Responsibilities
  • Lead the design, planning, execution, and interpretation of translational experiments using in vivo, ex vivo, and in vitro systems with an emphasis on human primary cell models
  • Generate insights from non-clinical experiments (cell biology and animal studies) to inform mechanism of action and clinical development
  • Analysis of clinical and non-clinical experiments using targeted (amino acids and derivatives, mitochondrial function, metabolic signaling pathways, stable isotope tracers) and untargeted (proteomic, metabolomic, transcriptomic) techniques
  • Reporting and documentation of research and non-clinical activities for regulatory purposes e.g. IND, filing
  • Represent Research in cross-functional Product Development Teams
  • Leverage a network of external CROs, scientific advisors, and consultants
  • Prepare effective materials for publications, posters and meetings, and corporate presentations
Skills and Attributes
  • Strong cell biology skills: knowledge of primary cell culture is required; experience with hepatocytes, myotubes and/or immune cells is strongly preferred
  • Proven track record of good experimental design, in-depth data analysis, and interpretation based on strong scientific rationale
  • Knowledge of regulatory space and knowledge of the role of research in early and late clinical development
  • Experience with summarizing and documenting research and non-clinical development for regulatory documents and submissions e.g. IND, filing
  • Good lab leadership, flexible, and able to work independently or collaboratively as part of a team in a highly dynamic, biotech environment
  • Proven ability to collaborate and communicate in a cross-functional environment with Clinical and/or Commercial teams
  • Ability and experience presenting your work, internally and externally
Education and Experience
  • Ph.D. in cell biology, biochemistry, molecular biology, or relevant field with a minimum of 8+ years of relevant experience.
Joining Axcella Health offers the potential to be part of a groundbreaking organization. We are growing quickly as we advance in the clinic, and we are seeking exceptional people to join our team. We value bright minds, collaborative spirits and a willingness to think outside the box.
EEO Statement: Axcella Health is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

Recruitment & Staffing Agencies: Axcella Health does not accept unsolicited agency resumes. Agency resumes will only be accepted if the agency is formally engaged by Axcella Health Human Resources.

*Axcella Health conducts Non-Investigational New Drug (IND"), Institutional Review Board-approved Clinical studies to evaluate the safety and tolerability of our AXA candidates in human subjects, or effects on the normal structure or function of the body. Studies intended at the time of initiation to support drug development will be conducted under an IND.