Scientist, Structural Biology & Protein Design

3 days left

TC Industries Of Canada Company
Cambridge, Massachusetts, US
Sep 06, 2021
Sep 20, 2021
Biology, Modeling
Employment Type
Full time
Salary Type
We are seeking an experienced individual to lead structure biology efforts for our newly discovered protein systems. Structure biology is a key component for translating our discovery into therapeutic application. As Principal Scientist, you will be responsible for developing structure biology pipelines through both internal initiatives and CROs. You are also expected to use structural knowledge to provide mechanistic insights of protein systems, and work with protein engineers to guide structure-based designs and evaluate protein engineering and product development projects. you will be working with highly interdisciplinary teams to meet deadlines, achieve team objectives and demonstrate key results. Previous industry experiences and management of a team and CROs are highly preferred.

Key Responsibilities:
  • Develop the current structure biology program to achieve high-resolution structures for multiple CRISPR systems
  • Leverage the structure information to support protein engineering and product development efforts
  • Provide structure-function insights to guide biochemical and mechanistic characterizations
  • Provide leadership and expertise in structure-based design and modeling
  • Perform protein expression and purification, crystallizing, X-ray structure determination and/or Cryo-EM structure determination through both internal initiatives and CROs
  • Interact and manage collaborations with both internal teams and CROs

Basic Qualifications:
  • A Ph.D in structure biology or related fields with additional 2-5 years of experiences
  • Demonstrated ability to solve multiple protein structures and tackle difficult problems with Cryo-EM and X-ray crystallography.
  • Extensive knowledge of protein purification, biophysical characterization, protein structure and function, with familiarity in structural modeling and design
  • Excellent project management and organizational skills
  • Strong knowledge of CRISPR gene editing technologies, DNA nuclease structure, function and engineering
  • Demonstrated experience in optimization and execution of protein expression and purification workflows to produce material suitable for testing in mammalian primary cells (Pharma / Biotech Process Development is a plus)
  • Proficiency with biochemical (enzymatic activity, protein: nucleic acid interactions) and bioanalytical (DLS, DSF, SEC-MALS) methods to evaluate protein quality/stability and determine optimal protein/RNP formulationsDetail-oriented with excellent organizational and communication skills
  • Must enjoy working in a fast-paced dynamic and highly collaborative environment
  • Excellent collaboration, communication, and interpersonal skills are required to work with cross departmental teams/functions to drive drug discovery projects
  • In-depth knowledge of molecular biology & library cloning techniques

Desired Qualifications:
  • Direct experience in protein engineering and methods for directed evolution in mammalian cell systems is strongly preferred
  • Familiarity with standard mammalian cell culture techniques, including methods for gene delivery including and lenti-viral pooled screening approaches is a plus
  • Familiarity with CMC manufacturing best practices is a plus but we are willing to train an otherwise qualified candidate
  • Demonstrated success in leading projects and mentoring junior team members
  • Industrial experience with managing external structural biology collaborations (CROs)
  • 2+ years of relevant industry experience is preferred but not required

Our Values:

Our values govern the work we do at Arbor, and we're hoping that they resonate as strongly with you as they do with us!
  • Astonishingly Connected: The best work happens when we do it together. At Arbor, we believe strong, clear communication is crucial to our success and emboldens collaboration in all of us.
  • Our People are Gems: And we treat each other as such by celebrating our growth and development. We invest in our team and encourage everyone to have both a learners mindset and a willingness to teach others.
  • Remarkably Mighty: You'll be intrigued when you take a closer look at Arbor. We approach our work with integrity and thoughtfulness. We are brave, which leads us to take smart risks and make bold discoveries.
  • Authenticity is Encouraged: From eating cheese puffs with chopsticks, to doing cartwheels on our balance beam, we're all about embracing your true self and showing up as you really are. Our differences make us extraordinary.

About Arbor:

Arbor Biotechnologies is a venture-backed startup based in Cambridge, MA, composed of a small team of scientists and engineers pushing the boundaries of discovery at the intersection of computer science and biotechnology. Using our diverse backgrounds ranging from machine learning to genome engineering to protein biochemistry, we are building a platform to uncover and characterize nature's inventions on an unprecedented scale to generate impactful applications in human health and sustainability.

We seek highly-motivated individuals with the dedication, integrity, and creative spirit needed to thrive in an innovative company. Working at Arbor offers a unique opportunity that combines the fast pace and growth opportunities of a startup with the intellectual rigor and creativity of academia. Our salaries are competitive, our benefits are generous, and our team is exceptional.

Arbor Biotechnologies is proud to be an inclusive workplace and an Equal Opportunity Employer.

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