Senior Scientist, Molecular and Cellular Biology

Senior Scientist, Molecular and Cellular Biology

GlaxoSmithKline (GSK) is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs but finding new ways to discover drugs.

The Genomic Immunology group sits within the Immunology Research Unit and has a presence at our growing Cambridge, MA (US) site and at our R&D hub in Stevenage (UK). Our group strives to explore rich data landscape (23andMe, UK Biobank, FinnGen) to derive and identify crucial therapeutic target insights associated with diseases with unmet need across therapeutic areas, to build drug hypotheses, and to validate potential new therapeutic targets by integrating our groundbreaking functional genomics experimental platform. This approach maximizes the probability of delivering successful clinical candidates, and ultimately helping people to do more, feel better and live longer.

Description:
The Genomic Immunology research team in Cambridge, MA is seeking a self-motivated, energetic and creative cell and molecular biologist with critical and innovative thinking to take part in the development of novel therapeutics. This individual will work independently and/or in partnership with dynamic cross-functional project teams in a multidisciplinary matrixed environment to investigate the biology of novel targets using functional molecular genomic tools and to make significant and high-impact contributions in multiple GSK drug discovery programs.

Responsibilities:
Perform hands-on experimentation using a wide range of molecular and cellular techniques suitable for drug target identification and validation.

Design and conduct human and rodent cell- and tissue-based immunoassays for target identification and validation.

Generate, analyze, interpret, present experimental results at various meetings to partners/collaborators and collaboratively plan experimental paths forward

Develop and execute new methods and protocols and proactively incorporate new technology or techniques into practice with minimal supervision

Generate study reports and maintain a detailed record of experiments in electronic lab notebooks in accordance with company policy

Share in responsibilities to support general lab functions
Why you?
Basic Qualifications:
Degree in biology, molecular biology, cell biology, immunology, biotechnology, or life sciences

MS with 3+ years, or BS with 5+ years of experience in molecular and cellular immunology, research and development, in an industrial, academic or government laboratory setting

1+ years hands-on experience in molecular biology techniques and proficiency in utilizing functional genomic editing tools

1+ years' experience in multicolor flow-cytometry analysis for phenotypic screening and target ID/validation in cell lines or primary immune cells

Preferred Qualifications:
Cell culture: Isolation and sterile tissue culture of mammalian cell lines and immune cell subsets

Cell-based assay development using primary rodent and human immune cells and immortalized cell lines

Molecular biology including but not limited to nucleic acid extraction and quality control, qPCR, NanoString, CRISPR gene editing, Microarray ,) Next Generation Sequencing (e.g. single cell RNA-Seq)

Multicolor Flow-cytometry analysis (set-up, acquisition, analysis and reporting)

Protein detection (included but not limited to ELISA, Luminex, MSD, Western blotting)

Pre-clinical animal models of autoimmune disorders

Previous drug discovery experience in a biopharmaceutical setting

Learning agility and drive to continuously improve and develop

Outstanding written and oral communication skills as well as excellent interpersonal skills

Why GSK?
Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.

Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.

Continuously looking for opportunities to learn, build skills and share learning.

Sustaining energy and well-being

Building strong relationships and collaboration, honest and open conversations.

Budgeting and cost-consciousness

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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We are a science-led global healthcare company with a special purpose: to help people do more, feel better, live longer. We have 3 global businesses that research, develop and manufacture innovative pharmaceutical medicines, vaccines and consumer healthcare products. We aim to bring differentiated, high-quality and needed healthcare products to as many people as possible, with our scientific and technical know-how and talented people. We strive to attract the best people and to create an environment that empowers and inspires. Explore more exciting opportunities by visiting our career site .