Associate Scientist / Senior Associate Scientist, Cellular and Molecular Neurobiology

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas' PROTAC Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas' pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes two clinical-stage programs: ARV-110, which is being developed as a potential treatment for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 200 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and purpose - to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It's an exciting time to be in drug development and it's an exciting time to be at Arvinas. But don't just take our word for it - here's what Arvinas employees are saying. For more information, please visit .

Position Summary

Join the rapidly growing team at Arvinas, the leader in developing therapeutic PROTAC-mediated protein degradation. This is a hands-on, laboratory based role, where your focus will be to support core scientific functions of the Cell and Molecular Biology team within the Dept. of Neurology. The successful candidate will bring a strong skillset in applied molecular and cell biology, including experience in stable cell line generation, iPS cell maintenance and differentiation into neural cell fates, as well as a commitment to teamwork.

This position reports to a Senior Research Scientist on our Neuroscience team and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Working with senior biologists on the CMB team to design and generate constructs for CRISPR gene editing, transduction or transfection
• Generate high titer lentiviral transduction reagents
• Differentiate, maintain, and apply quality control protocols to iPSC-derived neurons
• Contribute to the process of well-controlled in vitro biochemical and quantitative image-based immunocytochemistry assay design in neural cell types derived from iPSCs, and also in heterologous cell systems.
• Independently analyze & present data at project team meetings
• Think creatively about novel problems, and take initiative to explore solutions
• Maintain clear & organized experimental records & electronic laboratory notebook

Qualifications

• B.S./ M.S with 3+ years of experience in cellular and molecular biology, biochemistry, & assay development. Pharmaceutical or biotechnology industry experience preferred, but not required.
• Strong hands-on working experience with molecular biology technique, with a focus on manipulation of gene expression in vitro (shRNA, siRNA, and / or CRISPR)
• Hands-on cell culture experience required; experience differentiating iPSCs a plus.
  • Quantitation of proteins in cell and tissue lysates by ELISA, Western blotting, and related technique.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness, and financial security of our employees and their families. Benefits include group medical, vision, and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity Employer.