Scientist/Associate Scientist, Biology- High Throughput Screening

Employer
THIRD ROCK VENTURES, LLC
Location
San Francisco, California, US
Salary
Competitive
Posted
Aug 02, 2021
Closes
Aug 11, 2021
Ref
2311225829
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Scientist/Associate Scientist, Biology- High Throughput Screening at Pliant Therapeutics

Pliant Therapeutics is a public, clinical stage biopharmaceutical company focused on the discovery and development of novel therapies for fibrotic diseases. Founded by Third Rock Ventures with world-renowned academic thought leaders, Pliant is raising the bar to meet the unmet medical needs of physicians, patients and families impacted by fibrotic disease. The Company's focus is on mechanism-based intervention in the fibrotic process using small molecules. The Company's lead product candidate, PLN-74809, is an oral, small molecule selective inhibitor of the αvβ1 and αvβ6 integrins that play a key role in multiple fibrotic pathways. PLN-74809 has received Orphan Drug Designation from the U.S. Food and Drug Administration in both idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC), and are currently in Phase 2a clinical trials for these indications. Pliant's second product candidate, PLN-1474, is an oral, small molecule selective inhibitor of the αvβ1 integrin, in development as a potential treatment forlate-stage liver fibrosis under a partnership with Novartis. The Company also has discovery and development programs in oncology and muscular dystrophies. The Company is seeking passionate, creative, and dedicated individuals to join our team and contribute to our mission.
Description
Immediate openings are available for Scientist/Associate Scientist in Molecular and Cell Biology in the High-Throughput Screening (HTS) Group. This individual will join a dynamic and growing multidisciplinary team focused on screening and discovery of new drug candidates. The primary responsibility of this position will be in the development and execution, cellular phenotypic assays utilizing robotic liquid handling platforms. A key component of the position will be to provide regular, high quality assay results, plus develop and troubleshoot approaches to optimize and improve experimental procedures. The successful candidate will work with some direct supervision.
Responsibilities
  • Independently execute assigned assays and tasks following appropriate laboratory/technical procedures with special attention to data quality and reproducibility.
  • Analyze and record data, making detailed observations when required.
  • Evaluate and clearly report experimental results on a routine basis.
  • Develop new laboratory techniques, troubleshoot experiments, and ensure methods are well designed and performed to a high standard suggesting improvements when necessary.
Qualifications
  • B.S. or M.S degree in Molecular Biology or Biochemistry or Cell Biology
  • Minimum of 5 years' experience mammalian cell tissue culture working in a laboratory research environment in either industry or academia.
  • Broad practical experience and knowledge in common cell biology laboratory procedures (cell culture, fluorescent cell staining, microscopy, cell adhesion assays, ELISA, etc.).
  • Experience using biological assays to characterize small molecules, data graphing analysis is an advantage.
  • Experience with flow cytometry and liquid handling automation is desirable.
  • Ability to evaluate and clearly communicate results.
  • Exceptional interpersonal, verbal, and written communication skills

29 Newbury Street
3rd Floor
Boston, MA 02116
P (617) 585-2000