Cambridge, Massachusetts, US
Aug 02, 2021
Aug 04, 2021
Employment Type
Full time
Salary Type
Computational Scientist needed for a contract opportunity for Yoh Scientific's client located in the Cambridge, MA area. This position is with a major pharmaceutical company that makes cancer and immunology drugs. If you meet the requirements, please apply to this job and also feel free to follow up via email to (Job#319277)

Part time position: 10 hours / week for 3 months w2 contract
Pay rate: $60-$85/hour

We are looking for a computational scientist to work closely with Cancer Biology leads and interrogate our many disease hypotheses through the analysis of single cell and single nucleus expression datasets generated within our group. The candidate would help us leverage discrete high depth patient sample cohorts for translational research in exploring cancer vulnerabilities, particularly as they relate to various intrinsic cancer pathways or immune evasion mechanisms of interest to the group.

This individual will play a key role hands-on in processing Chromium 10X singe cell expression data from basic filtering, doublet detection, and cell clustering to more involved differential gene expression, co-expression analysis, and interrogation of target signatures of interest in cell phenotypes from tissue or circulating immune cells (PBMCs). The candidate will be expected to apply any needed normalization techniques to perform longitudinal treatment comparison or intra-patient tumor heterogeneity comparisons under scientific supervision. They will need to be well versed in pipelines or R-packages used in single cell expression analysis. Basic correlation of data outputs with clinical cohort data will also be performed.

The candidate will need to have great communication skills as they will interact with a diverse team of scientist on discrete projects. In turn, the position offers a computational biologist experience in translational research, biomarker discovery, mechanisms of resistance studies (to ImmunoOncology and stander of care treatment) particularly from clinically relevant cohorts

• This will be a part-time discrete project experience.
• Under the guidance of Cancer Biology (Translational medicine) scientist perform data analysis for 10x based single-cell and single-nucleus RNAseq data from patient tumor and PBMC samples, to support translational medicine efforts.
• Detailed analysis to include: basic data filtering, doublet detection, some intra-sample normalization, cell clustering using reference datasets (or machine learning techniques if possible), DEA comparisons, various activity signatures across cell phenotypes, target expression and co-expression analysis.
• In collaboration with TM scientists evaluate various hypothesis in such high dimensional datasets.
• Summarize analysis results to scientist and collaborate on further project development
• Help visualize findings for internal research communications as directed by scientist
• Integrate information from multiple modalities for mechanistic discoveries when possible (ie RNAseq with protein expression or accessibility epigenetic assays such as single cell ATACseq)

• Ph.D. or 3+ years of experience in computational biology, bioinformatics that included hands on experience with single cell RNAseq data analysis.
• Strong experience using R or other programming language for complex data analysis is required.
• Experience with reproducible research practices, including GitHub, is required.
• Experiences working with NGS, single-cell RNA-Seq analysis is required.
• Experience with analysis of single cell TCR seq and ATAC seq desired, ChIP-Seq a plus.
• Familiarity with cloud computing environments (Docker, AWS) is a plus.
• Expertise in application of modern machine-learning/AI approaches is a plus.Opportunity is Calling, Apply Now!

What's In It For You?

We welcome you to be a part of one of the largest global staffing companies to meet your career aspirations. Yoh's network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh's extensive talent community that will provide you with access to Yoh's vast network of opportunities and gain access to this exclusive opportunity available to you.

• Medical, Dental & Vision Benefits

• 401K Retirement Saving Plan

• Life & Disability Insurance

• Direct Deposit & weekly ePayroll

• Employee Discount Programs


Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. Visit to contact us if you are an individual with a disability and require accommodation in the application process.