Scientist - Cell Biology & Infectious Diseases

Chan Zuckerberg Biohub
San Francisco, California, US
Aug 02, 2021
Aug 18, 2021
Employment Type
Full time
Salary Type
The Chan Zuckerberg Biohub ("CZ Biohub) is a nonprofit medical research organization based in the San Francisco Bay Area, operating in partnership with UCSF, UC Berkeley and Stanford University. Our mission is to understand the fundamental mechanisms underlying disease and to develop new technologies that will lead to actionable diagnostics and effective therapies. We harness the power and possibility of collaboration to drive discovery and set the standard for open, impactful science. For more information, please visit [

As part of a new intramural collaborative effort that spans our Cell Atlas, Infectious Disease, and Technology Initiatives, we seek to comprehensively map how human cells get hijacked and remodeled during viral infection. In this context, we are investing resources and talent in cell biology, live-cell microscopy, biochemistry and genome engineering. One of our goals is to contribute open-source curated datasets that can be re-used by the entire community (see for example


We are seeking a Scientist to help establish an experimental and analytical pipeline to map how viruses remodel infected human cells and dissect associated molecular mechanisms (BSL-2 viral models). In collaboration with others at the Biohub, you will:

* Build reporter human cell lines, in particular by using CRISPR engineering

* Perform live-cell imaging (confocal microscopy, light sheet)

* Study protein networks using mass spectrometry-based proteomics

* Analyze datasets

* Author publications

* Mentor junior colleagues

You will be a key collaborator embedded in our Intracellular Architecture [ and Computational Microscopy [ groups. This is a great opportunity to be part of a collegial multi-disciplinary team that combines genomics, high-throughput live cell imaging, mass-spec proteomics and robotics to decipher disease mechanisms.


* Ph.D. in Cell Biology, Molecular Biology, Developmental Biology or a related field

* Proven track record in cellular imaging (in particular live-cell fluorescence microscopy) and quantitative image analysis

* Expert knowledge of cell biology and cellular organelles

* Strong foundation in cell culture and molecular biology (experience with CRISPR editing is a plus)

* Direct experience with infection models is not required but is a plus

* Coding experience (Python, R, Matlab or similar languages) is preferred

* General enthusiasm for cellular mechanisms, systems biology, and open-source science

* Must be highly collaborative, team-oriented, and have excellent written and oral communication skills

This is a full-time opportunity. No contractors, consultancies will not be considered.


We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.

CZ Biohub is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

Headhunters and recruitment agencies may not submit resumes/CVs through this website or directly to managers. CZ Biohub does not accept unsolicited headhunters and agency resumes. CZ Biohub will not pay fees to any third-party agency or company that does not have a signed agreement with CZ Biohub.