Scientist, AAV Vector Biology

Intellia Therapeutics
Cambridgeport, Massachusetts, US
Jul 30, 2021
Aug 11, 2021
Biology, Genetics
Employment Type
Full time
Salary Type
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:

As a Scientist in the AAV Vector Biology group, you will help advance Intellia's gene-editing platform and pipeline. This role will apply new approaches to design and optimize viral vectors for gene editing. The successful candidate will work cross-functionally with teams throughout the organization including disease biology, pre-clinical, manufacturing, and bioinformatics.

Key responsibilities include:
  • Independently plan and execute experiments to design and validate novel AAV vectors for gene editing.
  • Interpret and communicate data as part of multi-disciplinary teams
  • Regularly survey primary research literature and patents
  • Advanced experimental troubleshooting and optimization
  • Contribute to the strategy and direction of Intellia's platform and pipeline
  • Present findings internally and externally to cross-functional teams
  • Maintain a detailed electronic laboratory notebook

About You:

We are seeking an innovative scientist with experience optimizing and validating AAV vectors for gene therapy. The ideal candidate thrives on working collaboratively with multidisciplinary teams, displays outstanding communication skills, and is passionate about pioneering new gene-editing technologies to treat diseases. Other important qualities include:
  • Degree in Molecular/Cell Biology, Genetics, Virology, Synthetic Biology, Bioengineering, or a closely related field
  • Experience with one or more of the following:
    • Design and delivery of viral or non-viral vectors
    • Virus/Host interactions and immunogenicity
    • Gene editing technologies such as CRISPR/Cas9
    • AAV delivery and biodistribution in pre-clinical models
    • AAV vector biology
  • Hands-on experience with molecular biology methods including PCR, qPCR, DNA purification, SDS-PAGE, microscopy, and cloning
  • Hands-on experience with mammalian cell culture and sterile technique
  • Familiarity with AAV production and purification methods
  • Excellent bench skills with attention to detail and high standards for data integrity and quality
  • Strong communication skills with the proven ability to work collaboratively

Meet your Future Team:

The Platform Innovation team is a collaborative, energetic, and passionate group of individuals whose mission is to advance and differentiate Intellia's platform to enable curative therapies. You will join a team with vector design and production expertise, and work closely with leaders in the field of CRISPR/Cas9 gene editing. The candidate will have many opportunities to broaden his or her experience with multiple cutting-edge gene therapy technologies that advance Intellia's pipeline.

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, the candidate must be local to Cambridge MA, or open to relocating. While some of the day-to-day operations may be home-office based, maintaining a strong relationship with your teammates is critical for conveying your scientific expertise while fostering an environment for growth of young scientists interested in a career in the biotech industry. If you join us, you can expect to be part of a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team to make a difference in patients' lives.


EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.