Research Scientist - RNA Biology

Employer
Actalent
Location
Bothell, Washington, US
Salary
Competitive
Posted
Jul 30, 2021
Closes
Aug 06, 2021
Ref
2347793830
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Role Description:
We are seeking an experienced and creative leader to join our interdisciplinary R&D team with the focus on product development of therapeutic nucleic acids. This candidate will take the leading role within the R&D group to develop new products and applications. He/she will also drive collaboration and communication with our production team and biologics department.
Key Responsibilities:
• Lead a cross-functional team to propose, design, plan, and manage R&D projects with focus in gene and RNA therapeutics applications
• Develop and optimize large scale DNA and RNA production process
• Lead the research efforts on RNA design, modifications, and protein translation for mRNA and circular RNA.
• Synthesis and characterization of RNA and DNA constructs
• Define QC methods for the developed products/service
• Collaborate with and/or supervise the scientists and engineers on joint projects
• Transfer developed technologies to the production team and provide support as needed for process improvement, scale-up or troubleshooting
• Perform statistical data analysis and present the results
Skills:
- RNA
- RNA isolation
- RNA sequencing software
- RNA design
- enzymatic assay
- RNA assay
Top Skills Details:
RNA , RNA isolation, RNA sequencing software, RNA design, enzymatic assay, RNA assay
Additional Skills & Qualifications:
Qualifications:
- MSc or BS in Biochemistry, Molecular Biology, Synthetic Biology, Microbiology, Biomedical Engineering, or related biomedical field. BSc with a minimum of 3 year experience in the pharmaceutical company, biotech or related industries
- Proven ability to analyze multi-factorial data, provide conclusions and design next steps independently.
- Knowledgeable in nucleic acid chemistry, molecular/cellular mRNA metabolism and translation mechanism
- Understand RNA biology and RNA chemistry including structure simulation, design, modification and stability improvement
- Good molecular biology laboratory skills. Experience in nucleic acid amplification, in vitro transcription, primer/probe/vector design, enzymatic reactions, PCR, qPCR, next-generation sequencing, molecular cloning and large scale plasmid preparation
- Experience in process development for cGMP-compliant therapeutic nucleic acid production is a plus
- Experience in various qualification, quantification, and nucleic acid purification methods, e.g., PAGE, CE, HPLC, UPLC, NGS, etc, is preferred
- Ability to effectively collaborate in a dynamic, fast-paced, and cross-functional matrix environment
- Good documentation practices. Able to prepare documents including data summaries, technical, analytical, and scientific reports, and transfer the procedures to manufacturing
- Self-motivated and passionate. Comfortable to work in a fast-paced work environment
Experience Level:
Intermediate Leve
About Actalent:
Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions.
The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.