Senior Scientist, Discovery Biology Immuno-Oncology and Cell Therapy

Bristol Myers Squibb
Seattle, Washington, US
Jul 29, 2021
Aug 07, 2021
Employment Type
Full time
Salary Type
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Discovery Biology team is looking for an innovative, creative and driven drug discovery immunologist to help advance our portfolio of anti-tumor cell therapies and immuno-oncology products. The successful candidate will have expertise in subsets of tumor associated immunity and the tumor microenvironment including immune cell dysfunction, stromal biology, and myeloid suppression. In addition, the candidate will have experience in target hypothesis generation and validation using both cellular immunology and molecular skills. This scientist will work in a highly collaborative, fast paced environment involving multiple teams across the company.

Responsibilities include but are not limited to:
  • Identification of tumor microenvironment specific restrictions on immune cell infiltration and function and development of novel concepts to overcome these using cell engineering, biologic and small molecule therapeutic approaches
  • Independently conceive, develop and execute novel in vitro and ex vivo assays/models to evaluate cell therapy efficacy in the context of the tumor microenvironment
  • Project leadership and collaboration across multiple projects / roles in a matrixed environment and obtaining alignment across different functional groups to drive decision making
  • Designing and implementing critical studies required to drive hypothesis-driven research
  • Anticipate the need for contingencies and demonstrate flexibility through development of alternative strategies
  • Present project and strategic framework updates and recommendations to leadership teams across the company
  • Provide supervision of junior scientists
  • Maintaining cutting edge knowledge of relevant research fields

  • Ph.D. in immunology, immune-oncology or tumor immunology or M.S. with a minimum of 7 years of relevant work experience or B.S. with minimum of 12 years of relevant work experience in relevant fields
  • Experience with immune and oncology related cell types including subset of T cells, NK cells, macrophages, MDSCs, DCs, fibroblasts/stroma, transformed tumor cells
  • Experience with cutting edge technologies typically employed to assess immune cell function including but not limited to subset of Luminex, MSD, IncuCyte-based assays, multi-parameter flow cytometry, T cell activation assays, myeloid cell functional assays, heterotypic cell cultures, imaging technologies, molecular characterization of gene expression and protein expression (e.g. Taqman, western blot, Citeseq etc)
  • Demonstration of in-depth, scientific-directed, innovative thinking
  • Self-motivated and focused with project management-oriented thinking; able to work on multiple projects in a matrix environment
  • Ability to work well as both team member and as individual contributor is essential
  • Good communication skills for cross-functional, management and external interactions; excellent oral presentation skills are critical
  • Requires strong organizational skills to ensure thorough and timely documentation of experiments, and preparation of data for compiling reports and presentations to research and corporate teams
  • Experience with cellular therapy, myeloid cells, and/or fibroblasts is an advantage

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.