Senior Research Associate, Discovery Biology

American Society for Biochemistry and Molecular Biology

• Senior Research Associate, Discovery Biology

Senior Research Associate, Discovery Biology
Job Posting for Senior Research Associate, Discovery Biology

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to addressing the underlying cause of severe diseases by up-regulating protein expression with RNA-based medicines. Using the company's proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach Stoke is developing antisense oligonucleotides (ASOs) to selectively restore protein levels. The company's first compound, STK-001 is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. Dravet syndrome is one of many diseases caused by a haploinsufficiency, in which a loss of ~50% of normal protein levels leads to disease. The company is pursuing treatment for a second haploinsufficient disease, autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. Stoke's initial focus is haploinsufficiencies and diseases of the central nervous system and the eye, although proof of concept has been demonstrated in other organs, tissues, and systems, supporting the company's belief in the broad potential for its proprietary approach. Stoke is headquartered in Bedford, Massachusetts with offices in Cambridge, Massachusetts. For more information, visit https://www.stoketherapeutics.com/ or follow the company on Twitter at @StokeTx

Position Purpose:

Stoke is seeking to hire a Senior Research Associate with a strong background in cell and molecular biology research. The candidate will report to an Associate Principal Scientist in the Discovery Biology Group and support ongoing research efforts in developing oligonucleotide-based therapies. The candidate is expected to perform the following activities:

Key Responsibilities:

• Work in aseptic conditions and maintain cultures of various cell types.
• Screen and evaluate oligonucleotide-based drug candidates and plasmids in cell-based assays by nucleofection, transfection.
• Perform cell and molecular biology techniques such as RNA and protein isolation, RT-PCR, RT-qPCR, in 96 and 384 well formats.
• Perform protein assays- western blot, ELISA and MSD assays.
• Troubleshoot experiments, analyze and interpret data, participate in development of new assays.
• Maintain accurate documentation of experiments in electronic lab notebook (ELN).
• Write technical reports and protocols, with guidance from supervisor.
• Present research findings at group meetings and occasional company-wide and external meetings, as necessary.
• Work independently as well as collaborate with peers in a result-oriented research environment.

Requirements

Required Skills & Experience:

• Senior Research Associate: B.S. with a minimum of 5+years post-graduate experience in molecular and cell biology research, or M.S. with a minimum of 2 years post-graduate experience in molecular and cell biology research
• Strong hands-on experience in RNA isolation techniques RT-qPCR and protein assays.
• Mammalian cell culture and cell-based assays is a must.
• Experience with viral vectors is a plus but not required.
• Strong organizational and recordkeeping skills.

Location(s):

Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in Bedford, MA.

Travel:

This position will require 10-15% travel.

Benefits & Compensation:

Stoke Therapeutics offers comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Primary Caregiver Leave; a 401K program with company match, and an Employee Stock Purchase Program (ESPP). Compensation will be highly competitive for the industry and directly commensurate with experience.

Interested candidates should apply directly to the position listed on Stoke's website:

• Location:
  Bedford, Massachusetts, United States
• Position Title: Senior Research Associate, Discovery Biology

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