Scientist, Cell Biology - Center for Protein Degradation

Employer
Dana Farber Cancer Institute
Location
Boston, Massachusetts, US
Salary
Competitive
Posted
Jul 25, 2021
Closes
Aug 01, 2021
Ref
2348115721
Discipline
Biology
Employment Type
Full time
Salary Type
Salary
Dana-Farber Cancer Institute (DFCI) and Deerfield Management have created the Center for Protein Degradation (CPD) at DFCI. The goals of the CPD are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions. Join our highly interactive team of scientists where we are creating new avenues of therapeutic intervention.

The Center for Protein Degradation (CPD) is seeking a highly motivated individual to join the biology team as a SCIENTIST with a focus in studying the mechanisms of cancer cell-mediated effects of targeted protein degraders. The individual will collaborate with multiple research groups to identify biomarkers with an emphasis on the development and implementation of assays to support pre-clinical and translational research. The individual will work closely with internal research teams, external collaborators, and contract research organizations (CROs) to design and develop strategies that establish proof-of-concept efficacy, identify clinically actionable pharmacodynamic measures of efficacy, and assess potential for adverse effects. The candidate will provide insights that impact the direction of our research, while also driving lab-based innovations. The individual will regularly present progress to the rest of the group and leadership.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Requirements

Responsibilities

Independently plan, manage, and perform biological experiments. Develop project proposals, timelines and resource needs, working closely with the Portfolio Manager and leadership. Monitor milestones and ensure deliverables are completed on time
Collect and analyze experimental data and identify next steps based on outcomes
Train research technicians and other scientific staff in methods/techniques
Develop, perform, and analyze screening assays to evaluate the activity of degrader molecules
Develop, implement, and deliver mechanistic insights into the mode of action of targeted degrader molecules
Work closely with chemistry, biochemistry, and proteomics teams to guide compound optimization and project progression
Prepare presentations and present project status and outcomes at internal and external meetings
Interact and liaise with internal and experts, academic groups, and CROs to establish collaborations and projects
Pursue opportunities to publish research externally
Maintain clear and accurate records of experimental work (e.g., experimental methods, results/findings)

Qualifications

Minimum Requirements

PhD degree in molecular biology, biochemistry, or related disciplines
Expertise in cell-based screening assays including ELISA, viability, and luminescence or imaging-based fluorescence formats
Deep knowledge in cell biology, transcriptional regulation, and signaling pathways
Demonstrated leadership in research projects related to drug development or translational applications
Excellent communication and presentation skills
Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals
Demonstrated ability to work in a fast-paced and dynamic environment.
Ability to work independently as well as in a collaborative environment
Proficiency in all common Microsoft Office and GraphPad Prism software
Excellent organizational and prioritization skills. Strong attention to detail

Desirable

2 years of relevant postdoctoral experience (for example, in an industrial setting)
Background in oncology or immunology
Working knowledge of genomics and/or cell-based fluorescence imaging techniques
Experience in design and execution of FACS-based assays

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to