Principal Scientist, Computational Biology

Insmed Incorporated
Bridgewater, New Jersey, US
Jul 24, 2021
Aug 11, 2021
Employment Type
Full time
Salary Type
About Insmed:

Insmed is a growing global biopharmaceutical company powered by our purpose to deliver life-altering therapies to small patient populations experiencing big health problems. Our most valuable resource is our employees, and a patients-first mentality guides everything we do. Today, we are building a world-class team of talented individuals who are willing to challenge the status quo, solve problems, and work collaboratively and with a sense of urgency.

Come join us if you are ready to roll up your sleeves and be recognized for your efforts while working alongside team members who share your passion for serving patients and their families.

About the Role:

The candidate will work within a dynamic and multidisciplinary team focused on the design, engineering, and preclinical analysis of innovative biotherapeutic agents. Specifically, this position will help lead ongoing development and application of our cutting-edge computationally-driven protein engineering platform, collaborating closely with experimental scientists to develop next-generation biologics.

Additional representative responsibilities will include, but not necessarily be limited to, the following:
    • Develop and apply algorithms to simultaneously optimize diverse properties characterizing protein sequence, structure, and function, in order to engineer potent biotherapeutics
    • Develop and apply machine learning models to predict effects of combinations of mutations on protein structure, function, and interactions, learning from both general data as well as protein target-specific data
    • Develop and apply methods to design portfolios of protein engineering experiments, exploring and exploiting the design space around a biotherapeutic target
    • Develop and apply methods to integrate diverse experimental data to close the loop between design and evaluation in computationally-directed evolution of a biotherapeutic target

About You:

    • PhD in Computer Science, Bioinformatics, or Quantitative Biological Sciences required
    • Relevant postdoctoral or industry experience preferred

Knowledge and Experience:
    • Bioinformatics / computational biology required; computational structural biology or computational immunology helpful
    • Machine learning models and methods
    • Optimization algorithms and numerical methods
    • Programming in a collaborative team environment

    • Proficiency in Python or R required; experience with additional languages, particularly Java, and C++, helpful
    • Excellent communication skills (verbal and written)
    • Highly organized with a strong attention to detail, clarity, accuracy, and conciseness

  • Must successfully exhibit Insmed's five core corporate values of: Integrity, Collaboration, Accountability, Passion, and Respect; along with any other position specific competencies.
  • The successful candidate will thrive in a dynamic work environment and show a commitment to diversity in individuals and ideas.

  • Minimal travel

This role is to be filled outside Colorado.
  • Insmed is an Equal Opportunity Employer and will judge all applicants based on their qualifications for the job, without regard to race, color, sex, religion, national origin, age, disability or any other characteristics protected by applicable federal, state or local law.
  • Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.
  • Please note that we review every submission and we will keep all submissions on file for six months. Insmed is an Equal Opportunity Employer.