Senior Scientist, CAR and TCR Biology

Bristol Myers Squibb
Seattle, Washington, US
Jul 22, 2021
Jul 27, 2021
Employment Type
Full time
Salary Type
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The BMS Immuno-Oncology and Cell Therapy Thematic Research Center is dedicated to research supporting development of novel cellular therapies. Our goal is to revolutionize medicine by re-engaging the body's immune system to treat cancer.
The CAR and TCR Biology team is seeking a highly motivated immunologist to help us deliver on this critical goal. The successful candidate will innovate preclinical in vitro methods for identification and optimization of lead T cell therapeutic candidates. The ideal candidate will have in depth conceptual understanding of tumor-associated T cell biology and be able to identify relevant assays, as well as recognize the need for novel technologies, for assessing functionality of the engineered T cells.
Responsibilities include and are not limited to:
o Identification and conception of novel methods and tools for improving the T cell characterization workflow and for improving functions of engineered T cells; apply science-driven decision making on complex problems.
o Designing and executing studies required to drive hypothesis-driven research, through interpretation and synthesis of available data sets.
o Application of extensive knowledge of T cell biology including activation pathways, signaling pathways, and T cell differentiation.
o Managing and/or coordinating workflows in projects.
o Timely communication of study design and data in verbal and written forms; provide well prepared data packages for internal team meetings, external scientific reports, patent applications, and Investigational New Drug applications.
o Act as a functional mentor to team members, especially more junior colleagues.
o Represent the project team/sub-team in meetings. Work with collaborators, both external and internal.
o Ph.D. in immunology, immune-oncology, or tumor immunology, with a successful publication record and 2+ years of post-doctorate, drug R&D experience in industry.
o Experience with in vitro technologies typically employed to assess T cell functionality, including, and not limited to MSD, IncuCyte-based assays, imaging and multi-parameter flow cytometry for immuno-phenotyping, T cell activation and proliferation analysis.
o T cell biology expertise, able to apply skills, experience, and theoretical knowledge from relevant literature to shape scientific direction and approach on projects.
o Able to recognize problems and then recommend/develop appropriate solutions, to iteratively test specific hypotheses or innovate through a series of related experiments.
o Self-motivated and focused, with project management-oriented thinking and growth-oriented mindset.
o Ability to work productively both as team member and as individual contributor.
o Strong interpersonal skills for working with cross-functional teams. Good at listening to and coordinating with colleagues in a matrix environment.
o Strong organizational and prioritization skills to ensure thorough and timely documentation of experiments, as well as preparation of data for compiling reports.
o Able to conceptualize broader impacts of personal activities on projects and teammates.
Additional desired qualifications:
o Bioinformatics experience with NGS or related data sets.
o Candidates with scripting experience in R, Python and/or MATLAB for data-driven analytics are preferred.
o Assay development experience with CAR T or TCR T cells.
o Experience with high throughput screens, CRISPR screens, high-throughput functional T cell analysis, and experimental automation.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.
Company: Bristol Myers Squibb
Req Number: R1539681
Updated: 2021-07-22 01:57:18.093 UTC
Location: Seattle,Washington
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.