Principal Scientific Researcher - Structural Biology

San Francisco, California, US
Jul 21, 2021
Jul 27, 2021
Employment Type
Full time
Salary Type
Principal Scientific Researcher - Structural Biology

The Department of Structural Biology at Genentech has an exciting opportunity for a highly motivated Principal Scientific Researcher (PSR) with expertise in protein biochemistry and structural biology. This Principal Scientific Researcher will join a group focused on generation and optimization of recombinant proteins for drug discovery efforts and discovery research. Working with multiple groups across Genentech, the Researcher will be responsible for generating high-quality protein reagents to support small and large molecule drug discovery, high throughput screening, assay development and structural biology efforts. This role will involve considerable bench work, including the use of robotic platforms for protein purification, and protein characterization by biophysical & biochemical methods. Hands-on experience with X-ray crystallography, including sample preparation and crystallization is highly desirable. The individual will work independently at the bench and collaborate with colleagues across various functional areas to generate and communicate data to further research and drug discovery.
Required Qualifications:
The successful candidate must have either a BS/MS degree with ~6-10 years of experience or a PhD with 0-2 years of experience in Biochemistry, Chemical Biology, Structural Biology or a related discipline. Relevant experience in generating challenging proteins across a range of protein families is required. A record of achievement and collaboration, documented by peer-reviewed publications is highly valued.

Additional Desired Qualifications:

Strong candidates will have many of the following skills and attributes:

Working knowledge of construct design strategies.

Experience in protein expression systems such as E coli , mammalian or insect.

Hands-on experience designing and optimizing the production of challenging protein targets for structural and/or functional studies.

Experience in purification and assembly of multi-protein complexes.

Expertise with modern protein purification and chromatography techniques, and knowledgeable with operating AKTA chromatography systems as well as analytical HPLC systems.

Hands-on experience in protein crystallization, crystal optimization and harvesting for data collection.

Exposure to cryo-EM sample and grid preparation.

Proficiency with methods to characterize protein quality and purity, such as mass spectrometry, SEC-MALS/DLS, endotoxin assays, CD, and DSF/thermal shift assays.

Expertise with biophysical and biochemical protein-protein, protein-nucleic acid interaction techniques and/or functional assays.

Passion for exploring and developing new technologies.

Excellent communication, interpersonal and organizational skills.

Team-oriented, collaborative nature with fearless attitude to tackle long standing difficult problems in research and drug discovery.

Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page .

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